CAS No. 117977-21-6

Batch: Purity:98.81
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Rabeprazole Related Compound E Chemical Structure
Chemical Structure
Check the Rabeprazole Related Compound E product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methylsulfanyl]-1H-benzimidazole
CAS Number 117977-21-6
Molecular Formula

C18H21N3O2S
Molecular Weight (MW) 343.44
SMILES CC1=C(C=CN=C1CSC2=NC3=CC=CC=C3N2)OCCCOC
InChIKey BSXAHDOWMOSVAP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Rabeprazole Related Compound E (Rabeprazole thioether) is an active metabolite of the proton pump inhibitor rabeprazole that targets gastric H+/K+-ATPase. By modulating the gastric H+/K+-ATPase enzyme system, it inhibits the final step of gastric acid secretion in parietal cells. This activity leads to suppression of gastric acid release and modulation of intragastric pH levels, mediating downstream antisecretory functions. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 69 mg/mL (200.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 69 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.