CAS No. 1617495-03-0
Batch:
Purity:99.58
Chemical Structure
Check the
RA-190
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3Z,5Z)-1-[(2S)-2-amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;hydrochloride | |
|---|---|---|
| CAS Number | 1617495-03-0 | |
| Molecular Formula |
C28H23Cl5N2O2 |
|
| Molecular Weight (MW) | 596.76 | |
| SMILES | C1C(=CC2=CC(=C(C=C2)Cl)Cl)C(=O)C(=CC3=CC(=C(C=C3)Cl)Cl)CN1C(=O)C(CC4=CC=CC=C4)N.Cl | |
| InChIKey | UMWXLEVUBFNYIK-VCCJZKHWSA-N |
RA-190 is an orally active bis-benzylidene piperidone that serves as a potent and selective inhibitor of the proteasome ubiquitin receptor RPN13 (ADRM1). By binding to RPN13, RA-190 impairs proteasomal degradation of toxic polyubiquitinated proteins, which triggers an endoplasmic reticulum (ER) stress response, activates the downstream p53/p21 signaling axis, and ultimately promotes autophagy and apoptosis in multiple myeloma cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(167.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.