SMILES:

FC1=CC=C(C=C1)C(=C2CCN(CCN3C(=S)NC4=CC=CC=C4C3=O)CC2)C5=CC=C(F)C=C5
R59949 Chemical Structure
Chemical Structure
Check the R59949 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
CAS Number 120166-69-0
Molecular Formula

C28H25F2N3OS
Molecular Weight (MW) 489.58
SMILES FC1=CC=C(C=C1)C(=C2CCN(CCN3C(=S)NC4=CC=CC=C4C3=O)CC2)C5=CC=C(F)C=C5
InChIKey ZCNBZFRECRPCKU-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.