CAS No. 882531-87-5
Batch:
Purity:99.18
Chemical Structure
Check the
R1530
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-2,10-dihydropyrazolo[3,4-b][1,4]benzodiazepine | |
|---|---|---|
| CAS Number | 882531-87-5 | |
| Molecular Formula |
C18H14ClFN4O |
|
| Molecular Weight (MW) | 356.78 | |
| SMILES | COC1=C(F)C=C2C(=C1)N=C3NNC(=C3N=C2C4=CC=CC=C4Cl)C | |
| InChIKey | UOVCGJXDGOGOCZ-UHFFFAOYSA-N |
R1530 is an orally active, dual-acting mitosis and angiogenesis inhibitor that targets vascular endothelial growth factor receptor 2 (VEGFR2, and fibroblast growth factor receptor 1 (FGFR1,. By inhibiting receptor tyrosine kinase signalling and disrupting mitotic checkpoint control, R1530 suppresses endothelial cell proliferation, blocks tube formation, induces polyploidy, and promotes apoptotic cell death or senescence in solid tumor models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.