CAS No. 449808-64-4
Batch:
Purity:99.8
Chemical Structure
Check the
R1487
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one;hydrochloride | |
|---|---|---|
| CAS Number | 449808-64-4 | |
| Molecular Formula |
C19H19ClF2N4O3 |
|
| Molecular Weight (MW) | 424.83 | |
| SMILES | CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC4CCOCC4.Cl | |
| InChIKey | RQHSAIGGUWVOBG-UHFFFAOYSA-N |
R1487 is an orally bioavailable and highly selective inhibitor targeting p38α MAP kinase. By suppressing p38α activity, R1487 blocks the p38 MAPK signaling pathway, thereby inhibiting downstream phosphorylation of target transcription factors and pro-inflammatory cytokine production. This targeted inhibition effectively attenuates inflammatory cascade signaling and suppresses cellular stress responses, highlighting its utility in modulating p38 MAPK-dependent biological processes. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMF | 42 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.