CAS No. 66635-93-6
Batch:
Purity:99.66
Chemical Structure
Check the
(R)-Ketorolac
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid | |
|---|---|---|
| CAS Number | 66635-93-6 | |
| Molecular Formula |
C15H13NO3 |
|
| Molecular Weight (MW) | 255.27 | |
| InChIKey | OZWKMVRBQXNZKK-LLVKDONJSA-N |
(R)-Ketorolac is a selective allosteric inhibitor of the small GTPases Cdc42 and Rac1. It blocks GTP binding to both GTPases, thereby suppressing downstream signaling pathways including p21-activated kinase (PAK) activation. Consequently, (R)-ketorolac inhibits GTPase-mediated cell adhesion, migration, and invasion, highlighting its potential for repurposing as an anti-metastatic therapeutic in ovarian cancer. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.