CAS No. 1268524-71-5
Batch:
Purity:99.08
Chemical Structure
Check the
(R)-(-)-JQ1 Enantiomer
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1268524-71-5 | |
|---|---|---|
| Molecular Formula |
C23H25ClN4O2S |
|
| Molecular Weight (MW) | 456.99 | |
| SMILES | CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C |
(R)-(-)-JQ1 Enantiomer is the inactive stereoisomer of the potent BET bromodomain inhibitor (+)-JQ1. Unlike the active enantiomer (+)-JQ1, which targets BRD4 to suppress oncogenic transcription, (R)-(-)-JQ1 Enantiomer does not inhibit BRD4 target gene expression. Consequently, it is frequently utilized as a negative control compound in epigenetic and transcriptional regulation studies to confirm target-specific phenotypic effects of BET inhibition. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.