CAS No. 2133832-83-2
Batch:
Purity:99.42
Chemical Structure
Check the
R-IMPP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide | |
|---|---|---|
| CAS Number | 2133832-83-2 | |
| Molecular Formula |
C24H27N3O2 |
|
| Molecular Weight (MW) | 389.49 | |
| SMILES | COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43 | |
| InChIKey | OKTGXQMSOIQCTJ-HXUWFJFHSA-N |
R-IMPP is a small-molecule inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) secretion. PCSK9 plays a critical role in cholesterol homeostasis by mediating the lysosomal degradation of cell-surface low-density lipoprotein receptors (LDLR). Downregulation or inhibition of PCSK9 prevents LDLR destruction, thereby enhancing receptor recycling to the plasma membrane and increasing cellular clearance of circulating low-density lipoprotein cholesterol. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(197.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | 7 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.