CAS No. 2771208-83-2
Batch:
Purity:99.02
Chemical Structure
Check the
(R)-HTS-3 (GLXC-25878)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(2R)-2-(dimethylamino)-2-phenylethyl]-3,5-difluorobenzamide | |
|---|---|---|
| CAS Number | 2771208-83-2 | |
| Molecular Formula |
C17H18F2N2O |
|
| Molecular Weight (MW) | 304.34 | |
| InChIKey | SDNDFXUSMLLOMH-INIZCTEOSA-N |
Biological Activity
(R)-HTS-3 is a selective inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) (IC50 = 0.09 µM). By targeting LPCAT3 within the Lands cycle phospholipid remodeling pathway, it suppresses the incorporation of arachidonic acid into cellular membrane phospholipids and alters acyl-chain composition. Downstream, this depletion of polyunsaturated phospholipids mitigates lipid peroxidation and protects HT-1080 and 786-O cancer cells from RSL3-induced ferroptosis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.