CAS No. 1638497-26-3
Batch:
Purity:99.25
Chemical Structure
Check the
(R)-Avanafil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(3-chloro-4-methoxyphenyl)methylamino]-2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 1638497-26-3 | |
| Molecular Formula |
C23H26ClN7O3 |
|
| Molecular Weight (MW) | 483.95 | |
| SMILES | COC1=C(Cl)C=C(CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)C=C1 | |
| InChIKey | WEAJZXNPAWBCOA-MRXNPFEDSA-N |
Biological Activity
(R)-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a reported in vitro IC50 of 5.2 nM. By suppressing PDE5 enzymatic function, the compound blocks the hydrolysis of cyclic guanosine monophosphate (cGMP) and enhances nitric oxide/cGMP signaling. The resulting elevation of intracellular cGMP levels downstream promotes vascular smooth muscle relaxation and modulates cellular physiological responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(99.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.