CAS No. 879487-87-3
Batch:
Purity:99.92
Chemical Structure
Check the
R-268712
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[4-[2-fluoro-5-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]pyrazol-1-yl]ethanol | |
|---|---|---|
| CAS Number | 879487-87-3 | |
| Molecular Formula |
C20H18FN5O |
|
| Molecular Weight (MW) | 363.39 | |
| SMILES | CC1=NC(=CC=C1)C2=N[NH]C=C2C3=CC(=C(F)C=C3)C4=C[N](CCO)N=C4 | |
| InChIKey | JQGOCCALXFSRHZ-UHFFFAOYSA-N |
R-268712 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), also known as transforming growth factor-beta type I receptor. By inhibiting ALK5 kinase activity, R-268712 blocks TGF-beta-induced phosphorylation of Smad2 and Smad3, suppressing downstream TGF-beta/Smad signaling pathways. This inhibition reduces extracellular matrix production, attenuates epithelial-to-mesenchymal transition, and suppresses fibrotic phenotypes in cellular models. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.