CAS No. 875320-29-9
Batch:
Purity:97.01
Chemical Structure
Check the
Quisinostat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 875320-29-9 | |
| Molecular Formula |
C21H26N6O2 |
|
| Molecular Weight (MW) | 394.47 | |
| InChIKey | PAWIYAYFNXQGAP-UHFFFAOYSA-N |
Biological Activity
Quisinostat (JNJ-26481585) is a potent, orally active pan-histone deacetylase (HDAC) inhibitor targeting HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11. Inhibition of HDAC activity leads to accumulation of hyperacetylated histones H3 and H4, inducing cell cycle arrest, apoptosis, and suppression of cell proliferation across various hematologic and solid tumor models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.