CAS No. 130-95-0
Batch:
Purity:99.95
Chemical Structure
Check the
Quinine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | |
|---|---|---|
| CAS Number | 130-95-0 | |
| Molecular Formula |
C20H24N2O2 |
|
| Molecular Weight (MW) | 324.42 | |
| InChIKey | LOUPRKONTZGTKE-WZBLMQSHSA-N |
Quinine is a cinchona bark-derived alkaloid that acts as an antimalarial agent and a potassium channel inhibitor. It inhibits mSlo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of. By blocking potassium channels and disrupting cellular membrane potential, quinine alters ion homeostasis and impairs downstream cellular signaling, contributing to its antiparasitic biological activities. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.