CAS No. 60-93-5
Batch:
Purity:99.08
Chemical Structure
Check the
Quinine dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;dihydrochloride | |
|---|---|---|
| CAS Number | 60-93-5 | |
| Molecular Formula |
C20H24N2O2.2ClH |
|
| Molecular Weight (MW) | 397.34 | |
| InChIKey | NNKXWRRDHYTHFP-HZQSTTLBSA-N |
Biological Activity
Quinine dihydrochloride is an antiparasitic agent and Slo3 (KCa5.1) potassium channel inhibitor that targets mammalian sperm potassium conductance (KSper). By binding to hydrophobic side chains within the intracellular pore region of the Slo3 channel, it blocks potassium ion efflux, disrupting membrane hyperpolarization and sperm motility. Additionally, it exhibits antimalarial activity against Plasmodium species by interfering with parasitic hemoglobin degradation and intraerythrocytic development. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(198.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 79 mg/mL |
| Ethanol | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.