CAS No. 6151-30-0

Batch: Purity:98
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Quinacrine Dihydrochloride Dihydrate Chemical Structure
Chemical Structure
Check the Quinacrine Dihydrochloride Dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6151-30-0
Molecular Formula

C23H30ClN3O.2HCl.2H2O
Molecular Weight (MW) 508.91
SMILES CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.O.O.Cl.Cl

Biological Activity

Quinacrine Dihydrochloride Dihydrate is an acridine-derived DNA intercalating agent and antimalarial compound that acts as a small-molecule inhibitor of NF-kB signaling and an activator of the p53 pathway. By intercalating into DNA, quinacrine suppresses NF-kB-mediated transcription and activates p53-dependent apoptotic pathways, thereby inhibiting tumor cell proliferation and promoting apoptosis in various cancer cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (19.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gurova KV, et al. Proc Natl Acad Sci U S A. 2005;102(48):17448-53.

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Note: Technical data last updated: Sep 1, 2026.