CAS No. 90-18-6
Batch:
Purity:99.74
Chemical Structure
Check the
Quercetagetin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxychromen-4-one | |
|---|---|---|
| CAS Number | 90-18-6 | |
| Molecular Formula |
C15H10O8 |
|
| Molecular Weight (MW) | 318.24 | |
| SMILES | OC1=CC=C(C=C1O)C2=C(O)C(=O)C3=C(O)C(=C(O)C=C3O2)O | |
| InChIKey | ZVOLCUVKHLEPEV-UHFFFAOYSA-N |
Quercetagetin is a flavonoid and a selective, cell-permeable inhibitor of Pim-1 kinase (IC50 = 0.34 μM). As an ATP-competitive compound, it preferentially targets Pim-1 over Pim-2 and other serine/threonine kinases. In intact prostate cancer cells, inhibition of Pim-1 kinase activity by quercetagetin disrupts downstream oncogenic signaling pathways, resulting in dose-dependent cellular growth inhibition and suppressed proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(201.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.