CAS No. 944328-88-5
Batch:
Purity:97.65
Chemical Structure
Check the
QS11
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino]-3-phenylpropan-1-ol | |
|---|---|---|
| CAS Number | 944328-88-5 | |
| Molecular Formula | ||
| Molecular Weight (MW) | 567.69 | |
| InChIKey | DOKZLKDGUQWMSX-HKBQPEDESA-N |
Biological Activity
QS11 is an inhibitor of ARFGAP1 (EC50 = that activates the Wnt/β-catenin signaling pathway. By binding to ARFGAP1 and modulating intracellular protein trafficking, QS11 enhances β-catenin-mediated transcription. Consequently, QS11 suppresses the migration of breast cancer cells overexpressing ARFGAP1, demonstrating a key role in regulating membrane dynamics and oncogenic cell motility.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.