CAS No. 3546-41-6

Batch: Purity:99.83
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Pyrvinium pamoate Chemical Structure
Chemical Structure
Check the Pyrvinium pamoate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 3546-41-6
Molecular Formula

C75H70N6O6
Molecular Weight (MW) 1151.39
SMILES CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.CC1=CC(=C(N1C2=CC=CC=C2)C)C=CC3=[N+](C4=C(C=C3)C=C(C=C4)N(C)C)C.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)[O-])[O-])C(=O)O

Ordering Information

Biological Activity

Pyrvinium pamoate is an anthelmintic agent and potent allosteric activator of casein kinase 1α (CK1α) that functions as a Wnt/β-catenin signaling pathway inhibitor. By selectively activating CK1α, pyrvinium pamoate accelerates the phosphorylation and degradation of β-catenin, thereby repressing Wnt target gene transcription. This downregulates downstream oncogenic drivers and suppresses cell proliferation, migration, and survival in various Wnt-dependent cancer cell lines and tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 24 mg/mL (20.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.