CAS No. 122628-50-6

Batch: Purity:98
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Pyrroloquinoline Quinone Disodium Salt Chemical Structure
Chemical Structure
Check the Pyrroloquinoline Quinone Disodium Salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 122628-50-6
Molecular Formula

C14H4N2Na2O8
Molecular Weight (MW) 374.17
SMILES C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)[O-])C(=O)[O-].[Na+].[Na+]

Biological Activity

Pyrroloquinoline quinone disodium salt is an aromatic tricyclic o-quinone compound that functions as an essential redox cofactor for bacterial dehydrogenases and acts as an efficient electron transfer catalyst. It promotes cellular energy metabolism by stimulating CREB phosphorylation and upregulating PGC-1α expression, thereby activating downstream pathways that enhance mitochondrial biogenesis and respiratory function in mammalian cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
0.1M NaOH 5 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chowanadisai W, et al. J Biol Chem. 2010;285(1):142-52.

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Note: Technical data last updated: Sep 1, 2026.