CAS No. 10049-83-9

Batch: Purity:98.37
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Pyrithioxin Dihydrochloride Chemical Structure
Chemical Structure
Check the Pyrithioxin Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 10049-83-9
Molecular Formula

C16H22Cl2N2O4S2
Molecular Weight (MW) 441.39
SMILES Cl.Cl.CC1=NC=C(CSSCC2=CN=C(C)C(=C2CO)O)C(=C1O)CO

Ordering Information

Biological Activity

Pyrithioxin Dihydrochloride is a synthetic neurotropic agent and disulfide derivative of pyridoxine that acts as a central nervous system modulator with no inherent vitamin B6 activity. It reduces blood-brain barrier permeability to inorganic phosphate and enhances cerebral metabolic function. Additionally, the compound supports neuronal cellular homeostasis and antioxidant defense mechanisms, promoting protection against metabolic stress and maintaining neurovascular barrier integrity. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 88 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.