CAS No. 1228445-38-2

Batch: Purity:99.07
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Pyrintegrin Chemical Structure
Chemical Structure
Check the Pyrintegrin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(cyclopropylmethyl)-4-[[4-(6-hydroxy-3,4-dihydro-2H-quinolin-1-yl)pyrimidin-2-yl]amino]benzenesulfonamide
CAS Number 1228445-38-2
Molecular Formula

C23H25N5O3S
Molecular Weight (MW) 451.54
SMILES OC1=CC=C2N(CCCC2=C1)C3=NC(=NC=C3)NC4=CC=C(C=C4)[S;v6](=O)(=O)NCC5CC5
InChIKey QRJTZIJWDLJKQO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pyrintegrin is a 2,-disubstituted pyrimidine derivative that functions as a β1-integrin agonist. It enhances cell-extracellular matrix adhesion-mediated integrin signaling to promote the survival of dissociated human embryonic stem cells without disrupting pluripotency. In addition, activated β1-integrin signaling prevents damage-induced loss of focal adhesions and F-actin stress fibers, protecting podocytes against injury in models of nephropathy. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.