CAS No. 499-80-9

Batch: Purity:99.88
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2,4-Pyridinedicarboxylic acid Chemical Structure
Chemical Structure
Check the 2,4-Pyridinedicarboxylic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 499-80-9
Molecular Formula

C7H5NO4
Molecular Weight (MW) 167.12
SMILES C1=CN=C(C=C1C(=O)O)C(=O)O

Ordering Information

Biological Activity

2,4-Pyridinedicarboxylic acid (2,4-PDCA) is a small-molecule structural mimic of 2-oxoglutarate (2-OG) that acts as a competitive inhibitor of 2-OG-dependent oxygenases, such as prolyl 4-hydroxylase. By competing with the endogenous 2-OG cofactor and chelating active-site catalytic metal ions, it blocks oxygenase catalytic activity, thereby modulating downstream cellular functions including extracellular matrix formation, collagen biosynthesis, and oxygen-sensing pathway signaling. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (197.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 21 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.