CAS No. 217082-60-5

Batch: Purity:97.69
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[Pyr1]-Apelin-13 Chemical Structure
Chemical Structure
Check the [Pyr1]-Apelin-13 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
CAS Number 217082-60-5
Molecular Formula

C69H108N22O16S
Molecular Weight (MW) 1533.80
InChIKey GGMAXEWLXWJGSF-PEWBXTNBSA-N

Ordering Information

Biological Activity

[Pyr1]-Apelin-13 is an endogenous peptide agonist of the APJ receptor (hAPJ) with high binding affinity, predominantly identified in human myocardium and plasma. Activation of the APJ receptor downstream pathway regulates cardiovascular function and enhances cardiac contractility while modulating nociceptive signaling to produce analgesic effects. Consequently, [Pyr1]-Apelin-13 serves as a valuable research tool for investigating heart failure, cardiovascular homeostasis, and neuropathic pain mechanisms. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (65.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 25 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.