CAS No. 709-85-3
Batch:
Purity:99.95
Chemical Structure
Check the
PYCR1-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(4-bromophenyl)methyl]-N-methylprop-2-yn-1-amine | |
|---|---|---|
| CAS Number | 709-85-3 | |
| Molecular Formula |
C11H12BrN |
|
| Molecular Weight (MW) | 238.12 | |
| InChIKey | CZHICGIAKKAMAP-UHFFFAOYSA-N |
PYCR1-IN-1 acts as a small-molecule inhibitor of pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme in cellular proline biosynthesis. By targeting PYCR1, it disrupts proline synthesis and alters amino acid metabolic pathways, significantly decreasing intracellular proline levels within breast cancer cells. This loss of proline availability suppresses breast cancer cell proliferation and downstream oncogenic signaling pathways. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(201.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 48 mg/mL |
| Ethanol | 48 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.