CAS No. 89-82-7
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Chemical Structure
Check the
Pulegone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one | |
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| CAS Number | 89-82-7 | |
| Molecular Formula |
C10H16O |
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| Molecular Weight (MW) | 152.23 | |
| SMILES | CC1CCC(=C(C)C)C(=O)C1 | |
| InChIKey | NZGWDASTMWDZIW-MRVPVSSYSA-N |
Pulegone is a naturally occurring monoterpenoid compound that functions as an agonist of transient receptor potential melastatin 8 (TRPM8) and ankyrin 1 (TRPA1) ion channels. Activation of TRPM8 and TRPA1 by pulegone modulates intracellular calcium influx in sensory neurons, influencing cold thermal sensation and nociceptive signaling pathways. At elevated concentrations, pulegone exhibits target-dependent modulation by suppressing TRPM8 activity while maintaining activation of TRPA1 channels. [1]
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.