CAS No. 1919853-46-5
Batch:
Purity:99.95
Chemical Structure
Check the
PTP1B-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | methyl 5-[benzylsulfonyl-[[4-[(2-methoxy-2-oxoethyl)-methylsulfonylamino]phenyl]methyl]amino]-2-[(4-methylphenyl)methoxy]benzoate | |
|---|---|---|
| CAS Number | 1919853-46-5 | |
| Molecular Formula |
C34H36N2O9S2 |
|
| Molecular Weight (MW) | 680.79 | |
| SMILES | CC1=CC=C(C=C1)COC2=C(C=C(C=C2)N(CC3=CC=C(C=C3)N(CC(=O)OC)S(=O)(=O)C)S(=O)(=O)CC4=CC=CC=C4)C(=O)OC | |
| InChIKey | IPNJQCVHNPGYOX-UHFFFAOYSA-N |
Biological Activity
PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor. By inhibiting the dephosphorylation activity of PTP1B, this compound enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and activates downstream insulin signaling cascades. These molecular events lead to enhanced GLUT4 translocation and increased insulin-stimulated glucose uptake in target cells, demonstrating its key role in modulating metabolic signaling. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(146.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.