CAS No. 2924858-25-1
Batch:
Purity:99.86
Chemical Structure
Check the
PT-179
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)-5-morpholin-4-ylisoindole-1,3-dione | |
|---|---|---|
| CAS Number | 2924858-25-1 | |
| Molecular Formula |
C17H17N3O5 |
|
| Molecular Weight (MW) | 343.33 | |
| InChIKey | CCCSRHUSXCBFJZ-UHFFFAOYSA-N |
PT-179 is an orthogonal thalidomide derivative and molecular glue ligand targeting the Eubiquitin ligase substrate receptor cereblon (CRBN). Upon binding CRBN, PT-179 forms a ternary complex with target proteins fused to compact zinc finger degrons, such as SD40 or SDThis interaction recruits the ubiquitin-proteasome system to mediate rapid proteasomal degradation of tagged target proteins without causing off-target degradation of endogenous cellular proteins. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.