CAS No. 863329-66-2

Batch: Purity:99.89
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PSI-6206 (GS-331007) Chemical Structure
Chemical Structure
Check the PSI-6206 (GS-331007) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione
CAS Number 863329-66-2
Molecular Formula

C10H13FN2O5
Molecular Weight (MW) 260.22
SMILES CC1(C(C(OC1N2C=CC(=O)NC2=O)CO)O)F
InChIKey ARKKGZQTGXJVKW-VPCXQMTMSA-N

Biological Activity

PSI-6206 (GS-331007) is a nucleoside analog inhibitor targeting the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Intracellular conversion of PSI-6206 into its active triphosphate metabolite allows it to compete with natural nucleosides during viral RNA synthesis. Incorporation of the metabolite causes premature RNA chain termination, thereby disrupting HCV genomic replication and suppressing viral propagation in host cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 52 mg/mL (199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 52 mg/mL
Ethanol 24 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sofia MJ, et al. J Med Chem. 2010;53(19):7202-18.

[2] Antimicrob Agents Chemother. 2010;54(1):1-23.

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Note: Technical data last updated: Sep 1, 2026.