CAS No. 1180676-33-8
Batch:
Purity:99.21
Chemical Structure
Check the
PS47
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1180676-33-8 | |
|---|---|---|
| Molecular Formula |
C17H15ClO2 |
|
| Molecular Weight (MW) | 286.75 | |
| SMILES | OC(=O)\C=C(/CCC1=CC=C(Cl)C=C1)C2=CC=CC=C2 |
PS47 is an inactive E-isomer of PS48, functioning as a negative control compound for the allosteric activation of 3-phosphoinositide-dependent protein kinase 1 (PDPK1). Unlike PS48, PS47 fails to bind the hydrophobic motif PIF-pocket or induce allosteric conformational changes at the ATP-binding site of PDPK1. Consequently, it does not activate downstream PI3K/AKT pathway signaling, serving as a specificity tool in kinase studies.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.