CAS No. 1221962-86-2
Batch:
Purity:99.64
Chemical Structure
Check the
PS210
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1221962-86-2 | |
|---|---|---|
| Molecular Formula |
C19H15F3O5 |
|
| Molecular Weight (MW) | 380.31 | |
| SMILES | OC(=O)C(C(CC(=O)C1=CC=C(C=C1)C(F)(F)F)C2=CC=CC=C2)C(O)=O |
PS210 is a substrate-selective, allosteric activator of 3-phosphoinositide-dependent protein kinase 1 (PDK1) that targets the hydrophobic PIF-pocket docking site. Binding of PS210 to the PIF-pocket allosterically modulates PDK1 active site conformation, enhancing kinase activity toward substrates lacking a PIF motif while inhibiting phosphorylation of distinct targets. This selective activity modulates downstream PI3K/AKT signaling pathways to influence cellular survival and metabolic responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.