CAS No. 179474-81-8
| IUPAC Name | 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide | |
|---|---|---|
| CAS Number | 179474-81-8 | |
| Molecular Formula |
C18H26ClN3O3 |
|
| Molecular Weight (MW) | 367.87 | |
| SMILES | COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl | |
| InChIKey | ZPMNHBXQOOVQJL-UHFFFAOYSA-N |
Prucalopride (R-93877) is a selective, high-affinity 5-HT4 receptor agonist that displays high selectivity over other 5-HT receptor subtypes. Activation of 5-HT4 receptors stimulates adenylate cyclase and elevates intracellular cyclic AMP levels, triggering acetylcholine release in enteric neurons. This cholinergic pathway stimulation promotes gastrointestinal motility, enhances peristaltic reflexes, and facilitates intestinal transit without significant cross-reactivity at other monoamine receptors.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 74 mg/mL |
| Water | Insoluble |
| DMSO |
60 mg/mL
(163.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 38 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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