CAS No. 1398046-21-3

Batch: Purity:98.95
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Proxalutamide (GT0918) Chemical Structure
Chemical Structure
Check the Proxalutamide (GT0918) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[4,4-dimethyl-3-[6-[3-(1,3-oxazol-2-yl)propyl]-3-pyridinyl]-5-oxo-2-sulfanylideneimidazolidin-1-yl]-3-fluoro-2-(trifluoromethyl)benzonitrile
CAS Number 1398046-21-3
Molecular Formula

C24H19F4N5O2S
Molecular Weight (MW) 517.50
SMILES CC1(C)N(C(=S)N(C1=O)C2=C(F)C(=C(C=C2)C#N)C(F)(F)F)C3=CN=C(CCCC4=NC=CO4)C=C3
InChIKey KCBJGVDOSBKVKP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Proxalutamide (GT0918) is a second-generation androgen receptor (AR) antagonist that targets the ligand-binding domain of the receptor. Blockade of AR activation inhibits androgen-mediated nuclear translocation and prevents the transcription of downstream target genes. Disruption of androgen receptor signaling suppresses prostate cancer cell proliferation and impairs cellular survival phenotypes mediated through the AR pathway. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (193.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.