CAS No. 1225-55-4

Batch: Purity:99.99
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Protriptyline hydrochloride Chemical Structure
Chemical Structure
Check the Protriptyline hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine;hydrochloride
CAS Number 1225-55-4
Molecular Formula

C19H22ClN
Molecular Weight (MW) 299.84
SMILES CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl
InChIKey OGQDIIKRQRZXJH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Protriptyline hydrochloride is a tricyclic antidepressant that acts as a potent inhibitor of norepinephrine and serotonin reuptake. By selectively binding to and blocking the norepinephrine transporter and serotonin transporter, it prevents monoamine clearance from the synaptic cleft, resulting in enhanced synaptic neurotransmission and subsequent modulation of downstream G-protein coupled receptor signaling pathways in central nervous system models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (200.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.