CAS No. 130-86-9
Batch:
Purity:99.79
Chemical Structure
Check the
Protopine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one | |
|---|---|---|
| CAS Number | 130-86-9 | |
| Molecular Formula |
C20H19NO5 |
|
| Molecular Weight (MW) | 353.37 | |
| SMILES | CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3 | |
| InChIKey | GPTFURBXHJWNHR-UHFFFAOYSA-N |
Protopine is a plant-derived isoquinoline alkaloid that acts as a calcium channel antagonist, cholinergic modulator, and anti-platelet agent. It inhibits calcium influx through both voltage-gated and receptor-operated calcium channels, leading to the inhibition of platelet aggregation. Additionally, protopine suppresses inflammatory responses by downregulating inducible nitric oxide synthase and cyclooxygenase-2 expression via inhibition of the MAPK and NF-kB signaling pathways. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(84.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.