CAS No. 14222-60-7
Batch:
Purity:99.58
Chemical Structure
Check the
Protionamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-propylpyridine-4-carbothioamide | |
|---|---|---|
| CAS Number | 14222-60-7 | |
| Molecular Formula |
C9H12N2S |
|
| Molecular Weight (MW) | 180.27 | |
| SMILES | CCCC1=NC=CC(=C1)C(=S)N | |
| InChIKey | VRDIULHPQTYCLN-UHFFFAOYSA-N |
Protionamide is a thioamide antitubercular drug that functions as a prodrug targeting enoyl-ACP reductase (InhA) in Mycobacterium tuberculosis. Upon activation by the flavin monooxygenase EthA, protionamide forms a covalent adduct with NAD+ to inhibit InhA activity. This inhibition disrupts mycolic acid biosynthesis, compromising bacterial cell wall integrity and leading to potent bactericidal activity against Mycobacterium tuberculosis strains. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.