CAS No. 263717-53-9

Batch: Purity:99.53
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Propyl pyrazole triol (PPT) Chemical Structure
Chemical Structure
Check the Propyl pyrazole triol (PPT) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[1,3-bis(4-hydroxyphenyl)-4-propylpyrazol-5-yl]phenol
CAS Number 263717-53-9
Molecular Formula

C24H22N2O3
Molecular Weight (MW) 386.44
SMILES CCCC1=C([N](N=C1C2=CC=C(O)C=C2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
InChIKey IOTXSIGGFRQYKW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist that exhibits a-fold binding affinity preference for ERα over ERβ. By selectively activating ERα signaling pathways, PPT drives gene transcription and mediates physiological responses in target tissues. In preclinical animal models, PPT stimulation regulates estrogen-responsive gene expression, promotes uterine weight gain, and prevents ovariectomy-induced loss of bone mineral density and body weight gain. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 77 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.