CAS No. 1428629-70-2
Batch:
Purity:
Chemical Structure
Check the
Propargyl-PEG4-NHS ester
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1428629-70-2 | |
|---|---|---|
| Molecular Formula |
C16H23NO8 |
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| Molecular Weight (MW) | 357.36 | |
| SMILES | C#CCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
Propargyl-PEG4-NHS ester is a noncleavable, amine-reactive PEG linker widely utilized in antibody-drug conjugate (ADC) synthesis and bioconjugation applications. The NHS ester moiety selectively reacts with primary amines on antibodies or proteins to form stable amide bonds, while the terminal alkyne group enables click chemistry reactions with azide-containing payloads or probes. Incorporating a hydrophilic four-unit polyethylene glycol spacer enhances conjugate solubility and reduces aggregation in biological systems.
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.