CAS No. 66532-86-3

Batch: Purity:99.97
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Propacetamol hydrochloride Chemical Structure
Chemical Structure
Check the Propacetamol hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 66532-86-3
Molecular Formula

C14H20N2O3.HCl
Molecular Weight (MW) 300.78
SMILES CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C.Cl

Ordering Information

Biological Activity

Propacetamol hydrochloride is a water-soluble prodrug of paracetamol (acetaminophen) that functions as an analgesic and antipyretic agent. Upon enzymatic cleavage by plasma esterases, propacetamol liberates active paracetamol, which inhibits cyclooxygenase enzymes (COX-1 and COX-2) within the central nervous system. This inhibition attenuates prostaglandin E2 (PGE2) synthesis, modulating central nociceptive signaling pathways to reduce pain sensation and fever. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (199.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 60 mg/mL
Ethanol 30 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.