Clinical Trials

Numerous clinical trials evaluate interventions across diverse medical fields, ranging from advanced oncological indications—such as platinum-resistant and recurrent small cell lung carcinoma—to infectious and inflammatory diseases, including sepsis, influenza, Crohn disease, chronic periodontitis, and vaginitis. Spanning Early Phase 1 through Phase 4, these studies are sponsored by academic institutions, government organizations, and research hospitals such as the Mayo Clinic, National Institute of Allergy and Infectious Diseases, and Fayoum University Hospital. The trials encompass various recruitment statuses, including recruiting, active not recruiting, completed, and terminated.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07315165 RECRUITING
Allogeneic Hematopoietic Stem Cell Transplant (Allo-HSCT)
University of Nebraska
 2026-07-22 PHASE2
NCT06655649 SUSPENDED
Obstructive Sleep Apnea; Sleep
Johns Hopkins University
 2025-01-29 PHASE1
NCT05446571 RECRUITING
Pregnant Women; CMV Infected Fetuses
Assistance Publique - Hôpitaux de Paris
 2023-10-20 PHASE3
NCT07687264 NOT_YET_RECRUITING
PCOS (Polycystic Ovary Syndrome); Insulinemic Response; Overweight (BMI > 25)
University of Zurich
 2026-08-01
NCT07275580 NOT_YET_RECRUITING
Autoimmune Rheumatic Diseases; Tooth Extraction; Infection Prevention; Antibiotic Prophylaxis
University of Sao Paulo General Hospital
 2026-08-20 PHASE4
NCT06769126 RECRUITING
Extensive Stage Lung Small Cell Carcinoma; Lung Small Cell Carcinoma, A Subtype; Lung Small Cell Carcinoma, I Subtype; Lung Small Cell Carcinoma, N Subtype; Lung Small Cell Carcinoma, P Subtype
SWOG Cancer Research Network
 2025-11-06 PHASE2
NCT05973097 RECRUITING
Oral Lichen Planus
Peking University Third Hospital
 2023-07-30
NCT02657785 RECRUITING
Primary Central Nervous System Lymphoma
Navy General Hospital, Beijing
 2010-09 PHASE2; PHASE3
NCT07589322 RECRUITING
Obesity and Metabolic Syndrome
Tri-Service General Hospital (TSGH)
 2026-03-31
NCT07795047 NOT_YET_RECRUITING
Congenital Hyperinsulinism (CHI)
Odense University Hospital
 2026-09
NCT06184659 RECRUITING
Sepsis; Septic Shock
Scandinavian Critical Care Trials Group
 2025-06-26 PHASE4
NCT05912621 RECRUITING
Obesity; Overweight and Obesity; Overweight
Stanford University
 2023-11-09 PHASE2
NCT07603050 NOT_YET_RECRUITING
Gaucher Disease Type 3
Shanghai Vitalgen BioPharma Co., Ltd.
 2026-05-14 PHASE1; PHASE2
NCT05751668 SUSPENDED
Anatomic Stage IV Breast Cancer AJCC v8; Chemotherapy-Induced Peripheral Neuropathy; Metastatic Breast Carcinoma
Alliance for Clinical Trials in Oncology
 2023-11-02 PHASE2
NCT07483736 NOT_YET_RECRUITING
C15.378
Versailles Hospital
 2026-03 PHASE3
NCT07480850 ACTIVE_NOT_RECRUITING
Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2026-01-01 PHASE2
NCT07437170 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Pediatric Acute Myeloid Leukemia; NUP98 Fusion-positive Acute Myeloid Leukemia
The Children's Hospital of Zhejiang University School of Medicine
 2024-01-01 PHASE2
NCT07199218 RECRUITING
Autism; Autism Spectrum Disorder
Bazelet Nehushtan LtD.
 2025-10-05 PHASE2
NCT06673056 ACTIVE_NOT_RECRUITING
Ataxia-Telangiectasia; Ataxia-Telangiectasia (A-T)
IntraBio Inc
 2025-03-18 PHASE3
NCT06847399 RECRUITING
Obesity and Overweight; Binge Eating Disorder
Johns Hopkins University
 2025-09-17 PHASE2
NCT07453498 RECRUITING
Total Hip Arthroplasty (THA)
University College Hospital Galway
 2025-11-18
NCT06970262 WITHDRAWN
Lung Infection; Microbial Colonization; Food Intolerance Syndromes
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
 2026-09-20
NCT07560592 RECRUITING
Heart Failure
Maya Guglin, MD
 2026-01-21
NCT06544655 ACTIVE_NOT_RECRUITING
Advanced Solid Tumors
Bristol-Myers Squibb
 2024-10-10 PHASE1
NCT07690293 NOT_YET_RECRUITING
Cancer-related Fatigue
China Medical University Hospital
 2026-08-01
NCT02698254 ACTIVE_NOT_RECRUITING
Recurrent Brain Neoplasm
M.D. Anderson Cancer Center
 2016-07-20
NCT06747871 RECRUITING
Chronic Pain; Tobacco Use; Opioid Substitution Treatment
Duke University
 2025-04-15
NCT06802627 NOT_YET_RECRUITING
Lung Cancer; Lung Resection
Universidade do Porto
 2025-03-01
NCT07703137 ENROLLING_BY_INVITATION
Parkinson's Disease
University of Oklahoma
 2026-08-10
NCT07711522 NOT_YET_RECRUITING
Posterior Spinal Instrumentation Patients
Istanbul Medipol University Hospital
 2026-08-01 EARLY_PHASE1
NCT05332301 RECRUITING
Healthy Nutrition
Kirsten Bell
 2022-10-04
NCT07412444 RECRUITING
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease; Overweight
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
 2026-05-06
NCT06811324 RECRUITING
Obesity Prevention; Sarcopenia in Elderly; Cardiovascular Function; GLP - 1; Weight Loss
The University of Texas Health Science Center at San Antonio
 2026-04-01 PHASE2
NCT06126315 RECRUITING
Amyotrophic Lateral Sclerosis
Mario Negri Institute for Pharmacological Research
 2025-03-26 PHASE2; PHASE3
NCT04283513 SUSPENDED
Hemorrhagic Fever
U.S. Army Medical Research and Development Command
 2022-10-31 PHASE2
NCT07701473 NOT_YET_RECRUITING
Alveolar Ridge Deficiency; Alveolar Bone Loss
Cairo University
 2026-09-01
NCT05796193 ACTIVE_NOT_RECRUITING
Malaria
London School of Hygiene and Tropical Medicine
 2023-10-02
NCT06965296 NOT_YET_RECRUITING
Nicotine Dependence, Cigarettes
State University of New York at Buffalo
 2026-08-24
NCT07245771 RECRUITING
Obesity &Amp; Overweight
Ikaria Bioscience Pty Ltd
 2025-11-04 PHASE1; PHASE2
NCT06357247 SUSPENDED
Stroke
Virginia Commonwealth University
 2024-03-04
NCT06735599 RECRUITING
Hypertension (Without Type 2 Diabetes Mellitus); High Blood Pressure; Male; Female; Adult; Cognition; Endothelial Function (Reactive Hyperemia); Oxidative Stress; Diet; Overweight; Body Composition Measurement; Gut Microbiome; Arterial Stiffness; Caucasian Whites; Inflammation; Microvascular Function
Georgia State University
 2024-09-17
NCT04771416 SUSPENDED
Leukodystrophy, Globoid Cell
Gemma Biotherapeutics
 2022-02-24 PHASE1; PHASE2
NCT01804634 RECRUITING
Refractory and/or Relapsed Metastatic Solid Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2013-03-27 PHASE2
NCT07186413 ACTIVE_NOT_RECRUITING
Acne Vulgaris
Galderma R&D
 2025-09-23 PHASE3
NCT07695961 NOT_YET_RECRUITING
Nutrition; Health and Wellbeing; Aging; Time Restricted Eating; Bone Health
University of Manouba
 2026-06-15
NCT06451055 WITHDRAWN
Isolated Impaired Fasting Glucose
Emory University
 2026-06-01
NCT06934707 NOT_YET_RECRUITING
Type 1 Diabetes (T1D); Nutrition Therapy; Glycemic Control for Diabetes Mellitus
Hospital de Clinicas de Porto Alegre
 2025-04-20
NCT07616700 RECRUITING
IgA Nephropathy (IgAN)
Haisco Pharmaceutical Group Co., Ltd.
 2025-08-25 PHASE2
NCT05669820 RECRUITING
Glioblastoma
Peter Siesjö
 2024-01-15 PHASE2; PHASE3
NCT07063095 RECRUITING
Gram Negative Infections; Sepsis and Septic Shock
Angela HUTTNER
 2025-08-25 PHASE3
NCT06295250 RECRUITING
Depression; Economic Vulnerability; Anxiety; Culture Specific Symptoms
University of Massachusetts, Worcester
 2024-03-01
NCT05226169 RECRUITING
Advanced Gastric Carcinoma
Asan Medical Center
 2022-04-29 PHASE3
NCT07665658 RECRUITING
Attention Deficit Hyperactivity Disorder
Khyber Medical University Peshawar
 2026-03-01
NCT03989414 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Celgene
 2019-09-30 PHASE1; PHASE2
NCT05338190 RECRUITING
Primary Immune Thrombocytopenia (ITP)
Assistance Publique - Hôpitaux de Paris
 2022-11-14 PHASE3
NCT06452199 RECRUITING
Healthy; Healthy Nutrition
University of Aarhus
 2024-06-10
NCT04041310 ACTIVE_NOT_RECRUITING
Solid Tumor, Adult
Nouscom SRL
 2019-10-21 PHASE1; PHASE2
NCT07490288 RECRUITING
AML
Institute of Hematology & Blood Diseases Hospital, China
 2026-05-08
NCT06075914 RECRUITING
Sleep Deprivation; Nutritional Intervention
Ohio State University
 2023-05-01
NCT04607954 ACTIVE_NOT_RECRUITING
Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Extensive Stage Lung Small Cell Carcinoma; Refractory Extensive Stage Lung Small Cell Carcinoma
Mayo Clinic
 2020-12-04 PHASE2
NCT05672901 RECRUITING
Genitourinary Syndrome of Menopause
Stratpharma AG
 2023-04-04
NCT07302256 RECRUITING
Influenza
Shanghai Institute Of Biological Products
 2025-12-16 PHASE1
NCT07742826 RECRUITING
Impacted Mandibular Third Molar Extraction; Impacted Lower Third Molar; Impacted Wisdom Tooth
Final International University
 2024-09-03
NCT07058207 RECRUITING
Obesity; Solid Neoplasm; Stage II-IV; Curative Treatment
Institut d'Investigació Biomèdica de Bellvitge
 2025-07-22
NCT06049680 RECRUITING
Malnutrition, Child; Malnutrition; Essential Fatty Acid Deficiency (EFAD); Parenteral Nutrition Associated Cholestasis
Fresenius Kabi
 2024-10-28 PHASE4
NCT07476144 ACTIVE_NOT_RECRUITING
Smoking Behaviors
JT International SA
 2026-01-08 PHASE1
NCT07130513 RECRUITING
Krill Oil; Muscle Function; Grip Strength; Long-Term Conditions; Omega 3 Fatty Acids
University of Glasgow
 2025-08-18
NCT07008456 RECRUITING
Obese With Comorbidities; Obese Patients (BMI ≥ 30 kg/m²)
Aphaia Pharma US LLC
 2025-09-12 PHASE2
NCT07180446 ACTIVE_NOT_RECRUITING
Obesity &Amp; Overweight
Texas Christian University
 2026-01-18
NCT04662723 RECRUITING
Glomerulonephritis; Immunoglobulin A Nephropathy
Fondazione Schena
 2023-05-01 PHASE4
NCT07145788 COMPLETED
Fibromyalgia (FM); Chronic Pain
University Hospital Tuebingen
 2026-02-10
NCT06607861 COMPLETED
Pain Score (VAS)
Minia University
 2024-06-01 EARLY_PHASE1
NCT07521150 ACTIVE_NOT_RECRUITING
Melorheostosis
Yeditepe University
 2026-04-18
NCT07223216 ACTIVE_NOT_RECRUITING
Obesity
Biomea Fusion Inc.
 2025-10-23 PHASE1
NCT07021690 NOT_YET_RECRUITING
Type 1 Diabetes (T1D)
Steno Diabetes Center Copenhagen
 2025-06-30
NCT05864716 UNKNOWN
Effect of Drug
National Cheng-Kung University Hospital
 2024-10-01
NCT07089732 NOT_YET_RECRUITING
Obesity; Prediabetes
Chung Shan Medical University
 2025-08-08
NCT06933862 NOT_YET_RECRUITING
Malnourished Children
Indonesia University
 2025-05-15
NCT07207291 RECRUITING
Bacterial Infections; Urinary Tract Infections; Intra-Abdominal Infections; Respiratory Tract Infections
Joincare Pharmaceutical Group Industry Co., Ltd
 2025-08-22 PHASE1
NCT05775198 RECRUITING
Infertility, Female; IVF
Nadezhda Women's Health Hospital
 2023-03-01
NCT06863571 RECRUITING
Ischemic Stroke
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2025-04-12 PHASE3
NCT06700395 RECRUITING
Multiple Myeloma
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
 2024-11-28 PHASE1
NCT07371286 NOT_YET_RECRUITING
Alcohol Use Disorder; Supplementation; Intestinal Permeability
Assistance Publique - Hôpitaux de Paris
 2026-02
NCT05873127 COMPLETED
Feeding and Eating Disorders
Shanghai Mental Health Center
 2023-01-01
NCT06126354 WITHDRAWN
Insulin Resistance; Prediabetic State; Non-Alcoholic Fatty Liver Disease; Overweight and Obesity
Columbia University
 2024-07-01 PHASE1
NCT04475666 RECRUITING
Critical Illness; Nutrition Disorders
King Abdullah International Medical Research Center
 2020-09-21
NCT03889912 COMPLETED
Cutaneous Squamous Cell Carcinoma; Basal Cell Carcinoma
Regeneron Pharmaceuticals
 2019-04-11 PHASE1
NCT07448766 COMPLETED
Chronic Low-back Pain (cLBP)
Cairo University
 2024-09-01
NCT05084053 COMPLETED
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP); Multifocal Motor Neuropathy (MMN)
Takeda
 2022-01-19 PHASE3
NCT06145282 ACTIVE_NOT_RECRUITING
Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2023-12-28 PHASE1; PHASE2
NCT04572815 ACTIVE_NOT_RECRUITING
Hematologic and Lymphocytic Disorder; Hematopoietic and Lymphoid System Neoplasm
Fred Hutchinson Cancer Center
 2021-05-14 PHASE2
NCT07154979 COMPLETED
Oliceridine
Shiyou Wei
 2025-09-04
NCT06991426 NOT_YET_RECRUITING
Copd; Athletes
Federal University of São Paulo
 2025-07 PHASE4
NCT06968286 COMPLETED
Periodontitis Stage II
Suez Canal University
 2025-01-01
NCT02416388 RECRUITING
Acute Myeloid Leukemia (AML)
University Hospital, Angers
 2015-01 PHASE2; PHASE3
NCT06821867 COMPLETED
Skin Hydration; Skin Elasticity
Mastelli S.r.l
 2024-12-18
NCT05531279 UNKNOWN
Severe Aplastic Anemia
Institute of Hematology & Blood Diseases Hospital, China
 2022-06-05
NCT06668298 NOT_YET_RECRUITING
Old Age
Henan Provincial People's Hospital
 2024-11
NCT06368895 UNKNOWN
Hepatic Encephalopathy; Dysbiosis
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
 2021-04-07 PHASE1
NCT03872479 UNKNOWN
Leber Congenital Amaurosis 10; Inherited Retinal Dystrophies; Eye Diseases, Hereditary; Retinal Disease; Retinal Degeneration; Vision Disorders; Eye Disorders Congenital
Editas Medicine, Inc.
 2019-09-26 PHASE1; PHASE2
NCT04263597 COMPLETED
Hematopoietic Stem Cell Transplant
Children's Hospital Medical Center, Cincinnati
 2020-08-26 PHASE1; PHASE2
NCT07548541 COMPLETED
Anaerobic Performance; Cognitive Performance; Healthy Volunteers
Inonu University
 2025-04-01
NCT06498843 COMPLETED
Rhinitis; Sinusitis; Upper Respiratory Infections; Colds
YSLab
 2025-03-18
NCT06751121 COMPLETED
Helicobacter Pylori Infection; Helicobacter Pylori Infected Patients; Helicobacter Pylori Infected Subjects
Daewoong Pharmaceutical Co. LTD.
 2024-02-06 PHASE3
NCT05400161 COMPLETED
Postpartum Depression; Parenting; Parent-Child Relations; Child Development
Children's Hospital of Philadelphia
 2022-11-18
NCT07174895 COMPLETED
Osteoarthritis, Knee
Idlib University
 2021-08-06
NCT05393505 UNKNOWN
Neutropenic Fever
The University of Hong Kong
 2022-10-24 PHASE4
NCT05247788 COMPLETED
Alcohol Use
Mark Fillmore
 2022-02-02
NCT03897244 COMPLETED
Helicobacter Pylori Infection
National Taiwan University Hospital
 2019-05-30 PHASE4
NCT06576479 RECRUITING
Chronic Kidney Diseases; Protein-Energy Malnutrition
NIN Institute
 2018-07-10
NCT06539910 UNKNOWN
Knee Arthropathy; Anesthesia, Local
Alexandria University
 2024-08 PHASE4
NCT05896813 UNKNOWN
Newly Diagnosed Peripheral T-cell Lymphoma
The First Affiliated Hospital with Nanjing Medical University
 2023-03-01
NCT05877911 UNKNOWN
Epithelial Ovarian Cancer; Acute Kidney Injury Due to Circulatory Failure
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2023-05 PHASE2
NCT06154824 COMPLETED
Histamine; Cowhage
Aalborg University
 2023-12-15
NCT06377995 UNKNOWN
Chronic Neck Pain
Escola Superior de Tecnologia da Saúde do Porto
 2024-09
NCT05034029 UNKNOWN
Osteoarthritis
Guangzhou First People's Hospital
 2021-08-01
NCT05517213 COMPLETED
Multiple Myeloma
Affiliated Hospital to Academy of Military Medical Sciences
 2022-09-01
NCT04841434 COMPLETED
CNS Lymphoma
Charite University, Berlin, Germany
 2021-06-01 PHASE1; PHASE2
NCT06571188 COMPLETED
Post Operative Pain
Menoufia University
 2024-08-01
NCT06587503 UNKNOWN
Ebola Virus Disease; COVID-19
University of Birmingham
 2024-10 PHASE4
NCT07119749 COMPLETED
Muscle Soreness
University of Birmingham
 2023-09-01
NCT03810404 UNKNOWN
Supplementation; Sport
Poznan University of Physical Education
 2018-12-20 PHASE3
NCT06583785 UNKNOWN
Older Adults
University of Reading
 2023-12-05
NCT05855551 COMPLETED
Birth Weight; Small for Gestational Age at Delivery; Diet; Deficiency; Gestational Weight Gain
International Food Policy Research Institute
 2023-05-25
NCT05212688 COMPLETED
COVID-19
Royal Marsden NHS Foundation Trust
 2022-07-19 PHASE2
NCT05764824 COMPLETED
Cognitive Decline; Nutrition, Healthy; Brain Injuries
Brigham and Women's Hospital
 2023-10-01
NCT07194577 COMPLETED
Nutritional and Metabolic Diseases; Metabolic Syndrome
Universidad de Colima
 2023-01-05
NCT05564039 COMPLETED
Type 2 Diabetes
Eli Lilly and Company
 2022-11-30 PHASE4
NCT05497739 UNKNOWN
Gastric Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2022-06-28 PHASE2
NCT06351917 COMPLETED
Knee Joint Pain
RDC Clinical Pty Ltd
 2024-04-24 PHASE4
NCT07041866 COMPLETED
This Study Aimed to Evaluate the Impact of Fortified Biscuit Consumption on the Iron Status of School-aged Children in Rural Kaolack
Universite du Sine Saloum Elhadj Ibrahima Niasse
 2024-02-15
NCT06064279 WITHDRAWN
Stage IV NSCLC
VA Office of Research and Development
 2024-06-04 PHASE1; PHASE2
NCT05980494 COMPLETED
Sepsis; Critical Illness
Fayoum University Hospital
 2022-09-13
NCT05828758 UNKNOWN
Enteral Feeding Intolerance
Sohag University
 2023-04-24 PHASE2; PHASE3
NCT03950778 COMPLETED
Albumin Supplementation; Albumin Therapy; Sepsis
University of Pecs
 2023-03-04 EARLY_PHASE1
NCT05983562 UNKNOWN
Diabetes Mellitus, Type 2; Hyperglycemia; Ketosis
University of British Columbia
 2023-06-26
NCT07233460 COMPLETED
Type 2 Diabetes Mellitus; Symptoms and Signs; Patient
Hatice Demirağ, Ph.D
 2024-02-06
NCT06854666 COMPLETED
Tennis Elbow; Lateral Epicondylitis; Lateral Epicondylitis (tennis Elbow); PRP Injection; PRP and Physiotherapy
Rehasport Clinic
 2017-01-02
NCT05869526 COMPLETED
Sarcopenia
University of Glasgow
 2023-05-01
NCT06148974 COMPLETED
Healthy
Anne Nilsson
 2023-12-06
NCT05788497 TERMINATED
Haemorrhoids Without Complication
Faes Farma, S.A.
 2023-03-30 PHASE3
NCT06190860 UNKNOWN
Alveolar Process Atrophy; Smoking, Cigarette; Platelet-Rich Fibrin
Universidad de los Andes, Chile
 2022-05-29
NCT04129710 UNKNOWN
Recurrent/RefractoryPrimary Central Nervous System Lymphoma (PCNSL)
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2020-01-01 PHASE2
NCT04794218 UNKNOWN
Lassa Fever; Lassa Virus Infection
International AIDS Vaccine Initiative
 2021-06-23 PHASE1
NCT03802461 SUSPENDED
Infection
Susy Hota
 2019-03-22 PHASE2; PHASE3
NCT04166773 COMPLETED
Nonalcoholic Steatohepatitis
Eli Lilly and Company
 2019-11-19 PHASE2
NCT04632992 COMPLETED
Advanced Unresectable or Metastatic Solid Malignancy
Genentech, Inc.
 2021-01-13 PHASE2
NCT05015348 COMPLETED
Hyperlipidemias
Peking Union Medical College Hospital
 2021-12-01
NCT04294979 COMPLETED
Multiple Sclerosis
IRCCS San Raffaele Roma
 2020-02-01
NCT05812664 UNKNOWN
Enteral Feeding Intolerance
Umraniye Education and Research Hospital
 2023-12
NCT06000436 UNKNOWN
Cardiovascular Diseases
Necmettin Erbakan University
 2023-11
NCT05764668 UNKNOWN
Cough
DoCare Pharmaceutial Technology Co.,Ltd
 2022-11-15 PHASE3
NCT04856800 COMPLETED
Gestational Diabetes
University of Aarhus
 2021-12-01
NCT06168773 COMPLETED
Delirium in Old Age
Ain Shams University
 2022-11-01 PHASE2; PHASE3
NCT03491540 COMPLETED
Rectal Cancer Surgery
Assistance Publique - Hôpitaux de Paris
 2018-09-03 PHASE3
NCT04514692 TERMINATED
Cervix Cancer; Endometrial Cancer
Stanford University
 2021-02-01 PHASE1; PHASE2
NCT05207488 UNKNOWN
Overweight and Obesity
University of Illinois at Urbana-Champaign
 2021-10-01
NCT04999358 COMPLETED
Coronary Heart Disease; Low Protein Intake; Sarcopenia
Northumbria University
 2021-11-29
NCT07237113 COMPLETED
Damage Muscle
Instituto de Ciencias de la Salud, Universidad de O'Higgins
 2021-09-01
NCT05256017 COMPLETED
Trypanosomiasis, African; Trypanosoma Brucei Gambiense; Infection; Sleeping Sickness
Drugs for Neglected Diseases
 2021-12-30 PHASE2; PHASE3
NCT05419674 UNKNOWN
Helicobacter Pylori Infection
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2022-08-01 PHASE4
NCT01236560 COMPLETED
Brain Stem Glioma; Cerebral Astrocytoma; Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Spinal Cord Neoplasm
National Cancer Institute (NCI)
 2011-01-26 PHASE2; PHASE3
NCT04341636 COMPLETED
Periodontal Diseases; Dental Caries
King Abdulaziz University
 2023-05-15
NCT05095038 TERMINATED
Overweight and Obesity; PreDiabetes
University of Copenhagen
 2022-02-10
NCT04976023 COMPLETED
Allergic Rhinitis
Prof. Lin Zhixiu
 2022-04-12 PHASE2
NCT05541003 COMPLETED
Prader-Willi Syndrome; Obesity
Rutgers, The State University of New Jersey
 2023-01-06 PHASE2
NCT05515614 COMPLETED
Premature Birth; Breastmilk Collection; Postnatal Growth Restriction
Loma Linda University
 2022-08-17
NCT04769687 UNKNOWN
Chronic Renal Failure; Diabete Type 2; Systemic Inflammation
Centre Hospitalier Universitaire de Besancon
 2020-11-21 PHASE2
NCT06393621 COMPLETED
Prehypertension
National Chung Hsing University
 2018-07-26
NCT05728424 UNKNOWN
Helicobacter Pylori Infection
Aga Khan University
 2022-09-20 PHASE3
NCT05328583 UNKNOWN
Human Immunodeficiency Virus-1 (HIV-1) Infection
RetroLead (Shanghai) BioPharma Co., Ltd.
 2022-04-15 PHASE1
NCT05658900 UNKNOWN
Jaw Cysts
Hams Hamed Abdelrahman
 2022-05-19
NCT05102162 TERMINATED
Pneumonia
University of Florida
 2021-12-17 PHASE4
NCT05018923 UNKNOWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2021-08-24 PHASE4
NCT05700851 COMPLETED
Chronic Kidney Disease Requiring Chronic Dialysis
University of Nottingham
 2022-09-27
NCT03719664 UNKNOWN
HIV-1-infection
Frontier Biotechnologies Inc.
 2018-12-17 PHASE2
NCT05318495 UNKNOWN
Adenoma; Colo-rectal Cancer
Dr. Horst Schmidt Klinik GmbH
 2022-03-01
NCT03871491 COMPLETED
Maternal Death; Maternal Infections Affecting Fetus or Newborn; Neonatal SEPSIS; Maternal Sepsis During Labor; Neonatal Death; Postpartum Sepsis
NICHD Global Network for Women's and Children's Health
 2020-09-01 PHASE3
NCT04753580 COMPLETED
Healthy Volunteers; Frail Volunteers
University Hospital, Clermont-Ferrand
 2021-10-04
NCT03164967 COMPLETED
Humoral Immune Response
ADMA Biologics, Inc.
 2016-12-29 PHASE4
NCT05507801 COMPLETED
Appetitive Behavior; Gastric Emptying; Physical Activity; Energy Intake
University of Reading
 2021-11-19
NCT04064528 COMPLETED
Aging
Purdue University
 2019-09-06
NCT04871971 COMPLETED
Healthy
Oxford Brookes University
 2021-09-15
NCT04755530 COMPLETED
Overweight or Obesity; Metabolic Syndrome
Faidon Magkos
 2021-02-25
NCT05457400 COMPLETED
Sugar; Blood, Low
Alpha Republic GmbH
 2022-04-28 PHASE1
NCT04165239 COMPLETED
Mitochondrial Diseases; Mitochondrial Myopathies; Mitochondrial Encephalomyopathies; MELAS Syndrome; MIDD
Khondrion BV
 2019-10-30 PHASE2
NCT05249374 COMPLETED
Hepatic Ascites
Beijing Protgen Biotechnology Development Co., Ltd.
 2021-10-14 PHASE1
NCT05292300 COMPLETED
Insulin Resistance; Obesity; PreDiabetes
Marmara University
 2021-05-24
NCT02461537 COMPLETED
Acute Myeloid Leukemia
DKMS gemeinnützige GmbH
 2015-09-17 PHASE3
NCT04540406 COMPLETED
Suspected or Confirmed COVID-19
Notitia Biotechnologies Company
 2021-11-02 PHASE2
NCT05104762 COMPLETED
Guillain-Barre Syndrome
Assiut University
 2021-09-01 PHASE2; PHASE3
NCT05252962 COMPLETED
Healthy
Rousselot BVBA
 2021-11-26
NCT04902456 UNKNOWN
Bimaxillary Protrusion
Future University in Egypt
 2020-12-29
NCT04095520 COMPLETED
Dental Erosion
Yuzuncu Yil University
 2019-09-01
NCT04791475 COMPLETED
Brachial Plexus Block; Dexmedetomidine; Dexamethasone; Bupivacaine
Tribhuvan University Teaching Hospital, Institute Of Medicine.
 2021-02-22
NCT04147767 UNKNOWN
Hypercholesterolemia; Breast Cancer; Obesity
University of Leeds
 2020-02-10
NCT03692507 UNKNOWN
Major Abdominal/GI Surgery
University of California, San Francisco
 2021-07-30
NCT03614221 COMPLETED
Atopic Dermatitis
Chang Gung Memorial Hospital
 2019-06-03 PHASE2
NCT04836013 UNKNOWN
Diarrhea Caused by Drug; Abdominal Pain
Università degli Studi dell'Insubria
 2021-05-13
NCT04773301 COMPLETED
Hip Fractures
Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
 2021-02-13 PHASE4
NCT03801902 COMPLETED
Locally Advanced Lung Non-Small Cell Carcinoma; Locally Recurrent Lung Non-Small Cell Carcinoma; Stage II Lung Cancer AJCC v8; Stage III Lung Cancer AJCC v8; Unresectable Lung Non-Small Cell Carcinoma
National Cancer Institute (NCI)
 2019-10-28 PHASE1
NCT06236659 COMPLETED
Diet; Food; Nutrition
Rob Erskine
 2019-12-01
NCT05140928 COMPLETED
Gastrointestinal Microbiome; Immunoglobulin A; Growth; Stunting, Nutritional
Andalas University
 2020-08-20
NCT04865952 COMPLETED
Wound Heal; Wound Surgical; Oral Soft Tissue Conditions; Hyaluronic Acid
University of Roma La Sapienza
 2021-04-29
NCT06585319 COMPLETED
COVID 19
Materno-Perinatal Hospital of the State of Mexico
 2020-02-01 PHASE2; PHASE3
NCT04769726 COMPLETED
Intervention
Diabetes Foundation, India
 2017-12-16
NCT04872530 COMPLETED
Bioavailability of Amino Acids Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men
University of Limerick
 2020-01-08
NCT05687409 COMPLETED
Cirrhosis, Liver; Metagonimiasis
First Affiliated Hospital of Zhejiang University
 2019-11-24 PHASE4
NCT04451330 COMPLETED
Acne Vulgaris
Galderma R&D
 2020-07-29 PHASE4
NCT03043183 UNKNOWN
Nutrition Disorders
The First Hospital of Jilin University
 2017-03-01
NCT04035330 UNKNOWN
Necrotic Pulp
Cairo University
 2019-09
NCT04969536 COMPLETED
Healthy
Montana State University
 2019-10-01
NCT04569786 TERMINATED
Coronavirus Disease (COVID-19)
Merck Sharp & Dohme LLC
 2020-10-29 PHASE1
NCT04107194 UNKNOWN
Helicobacter Pylori Infection; Antibiotic Resistant Infection; Antibiotic Resistant Strain
University of Bari
 2020-01-14 PHASE3
NCT04235426 UNKNOWN
Carpal Tunnel
Dalia Salah Saif
 2018-01-26 PHASE1
NCT04921579 COMPLETED
Bimaxillary Protrusion
Future University in Egypt
 2019-12-15
NCT03732807 COMPLETED
Alopecia Areata
Pfizer
 2018-12-03 PHASE2; PHASE3
NCT02142803 ACTIVE_NOT_RECRUITING
Adult Glioblastoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Serous Adenocarcinoma; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Malignant Uterine Corpus Neoplasm; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Solid Neoplasm; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
National Cancer Institute (NCI)
 2014-05-20 PHASE1
NCT03568643 COMPLETED
Uncomplicated Severe Acute Malnutrition
University of California, San Francisco
 2020-06-03 PHASE3
NCT04468958 COMPLETED
COVID-19; SARS-CoV2
SAb Biotherapeutics, Inc.
 2020-07-01 PHASE1
NCT02991937 COMPLETED
Appendicitis
NYU Langone Health
 2016-12 PHASE4
NCT03802318 UNKNOWN
Helicobacter Pylori Infection; Helicobacter Gastritis; Helicobacter-Associated Pyloric Ulcer
Chang Gung Memorial Hospital
 2019-01-02
NCT04360122 UNKNOWN
Coronavirus Disease (COVID-19)
Ain Shams University
 2020-05-20 PHASE3
NCT04042077 TERMINATED
Surgical Site Infection
Menarini Group
 2019-09-25 PHASE3
NCT04444388 COMPLETED
Healthy Athletes
Universidad Europea de Madrid
 2020-07-01
NCT02283905 TERMINATED
Blastomycosis
University of Manitoba
 2015-06 PHASE4
NCT03850535 TERMINATED
Acute Myeloid Leukemia
Hoffmann-La Roche
 2019-03-25 PHASE1; PHASE2
NCT03639142 UNKNOWN
Functional Constipation
Medical University of Warsaw
 2018-09-01 PHASE3
NCT02942277 COMPLETED
Malaria
National Institute of Allergy and Infectious Diseases (NIAID)
 2016-10-21 PHASE1
NCT03681054 ACTIVE_NOT_RECRUITING
Diabetes, Gestational; Dietary Modification; Glucose Intolerance During Pregnancy; Body Composition; Birth Weight
Helsinki University Central Hospital
 2018-12-03
NCT03172676 UNKNOWN
Immune Thrombocytopenia
Assiut University
 2020-01-01 PHASE4
NCT02904772 WITHDRAWN
LPL Deficiency
UniQure Biopharma B.V.
 2016-10 PHASE2
NCT03535480 UNKNOWN
Premature Ovarian Failure (POF)
Instituto de Investigacion Sanitaria La Fe
 2018-06 PHASE4
NCT04223349 COMPLETED
Healthy
Janssen Research & Development, LLC
 2020-01-10 PHASE1
NCT03272542 COMPLETED
Obesity
San Francisco Veterans Affairs Medical Center
 2017-11-21 PHASE2
NCT04051476 COMPLETED
Thermogenesis by Different-dosage Ginger Flour Footbaths
ARCIM Institute Academic Research in Complementary and Integrative Medicine
 2019-09-16
NCT03920059 TERMINATED
Lupus Nephritis
Chulalongkorn University
 2019-08-20 PHASE4
NCT02920008 COMPLETED
Acute Myeloid Leukemia
Astex Pharmaceuticals, Inc.
 2017-03-16 PHASE3
NCT03680911 TERMINATED
Anosmia; Head Trauma
University of Miami
 2018-10-12 PHASE3
NCT04738994 COMPLETED
Cardiac Rehabilitation
Fondazione Don Carlo Gnocchi ETS
 2018-05-25
NCT03622424 COMPLETED
Overweight and Obesity; PreDiabetes; Type2 Diabetes
Gelesis, Inc.
 2017-08-22
NCT03584802 TERMINATED
Exacerbation of Idiopathic Pulmonary Fibrosis
Assistance Publique - Hôpitaux de Paris
 2019-05-16
NCT00058422 COMPLETED
Lymphoma
Memorial Sloan Kettering Cancer Center
 2003-02-10 PHASE2
NCT03211156 COMPLETED
Vaginitis Gardnerella
National Institute of Allergy and Infectious Diseases (NIAID)
 2017-09-11 PHASE2
NCT03795792 COMPLETED
Metabolic Syndrome
Coordinación de Investigación en Salud, Mexico
 2018-05-06
NCT02174263 WITHDRAWN
Graft Versus Host Disease
Fred Hutchinson Cancer Center
 2016-02 PHASE2
NCT03694821 TERMINATED
Osteoarthritis
UConn Health
 2018-07-05 PHASE4
NCT03885804 COMPLETED
Pain, Postoperative
Ain Shams University
 2019-03-20 EARLY_PHASE1
NCT03789227 COMPLETED
Pain, Chronic
Mansoura University
 2018-07-01
NCT02835339 COMPLETED
Preeclampsia
Oregon Health and Science University
 2016-07-12 PHASE4
NCT00392327 COMPLETED
Anaplastic Medulloblastoma; Medulloblastoma
Children's Oncology Group
 2007-05-23 PHASE3
NCT02947867 UNKNOWN
Ischaemic Central Retinal Vein Occlusion; Neovascular Glaucoma
Gene Signal SAS
 2017-01 PHASE2; PHASE3
NCT03519165 COMPLETED
Ovarian Cancer
Tata Medical Center
 2016-06
NCT05335824 COMPLETED
Class II Division 1 Malocclusion
Damascus University
 2019-02-08
NCT03868683 COMPLETED
Diabetes Mellitus, Type 2; Obesity; PreDiabetes
Singapore Institute of Food and Biotechnology Innovation
 2018-08-20
NCT03315338 COMPLETED
Healthy
Corcept Therapeutics
 2017-09-15 PHASE1
NCT03190369 COMPLETED
Osteoarthritis
Genzyme, a Sanofi Company
 2017-08-21 PHASE3
NCT03499457 UNKNOWN
Penicillin Allergy
Clalit Health Services
 2018-06
NCT03697499 COMPLETED
Cardiovascular System; Respiratory System; Oxidative Stress; Inflammation
Fudan University
 2018-09-20
NCT03291249 WITHDRAWN
NASH - Nonalcoholic Steatohepatitis; NAFLD; T2DM (Type 2 Diabetes Mellitus)
Tiziana Life Sciences LTD
 2017-12-01 PHASE2
NCT00777244 UNKNOWN
Adrenocortical Carcinoma
University of Turin, Italy
 2008-04 PHASE3
NCT02561962 COMPLETED
Multiple Myeloma
Amgen
 2015-11-20 PHASE1
NCT03421262 UNKNOWN
Gestational Diabetes
Hospital Mutua de Terrassa
 2017-06-01
NCT05029297 COMPLETED
Diabetic Neuropathy, Painful
Arafarma Group, S.A.
 2010-11-04 PHASE3
NCT02839876 COMPLETED
Osteoarthritis; Acetaminophen; Arthroplasty, Hip Replacement
Duke University
 2017-03-14 PHASE4
NCT03131687 COMPLETED
Type 2 Diabetes Mellitus
Eli Lilly and Company
 2017-05-24 PHASE2
NCT02603822 COMPLETED
Impaired Small Intestinal Permeability
Mayo Clinic
 2015-08 PHASE1
NCT04997122 COMPLETED
Healthy; Hypercholesterolemia
Instituto de Ciencia y Tecnología de Alimentos y Nutrición
 2018-04-02
NCT03615651 COMPLETED
Probiotics; Gut Microbiota; Emotional Stress; Magnetic Resonance Imaging
Örebro University, Sweden
 2018-01-22
NCT03203824 COMPLETED
Healthy
Loma Linda University
 2017-09-05
NCT03134352 COMPLETED
Eczema
Zai Lab Pty. Ltd.
 2017-04-26 PHASE2
NCT03711682 COMPLETED
Type 2 Diabetes Mellitus
Universidad Dr. José Matías Delgado
 2018-03-01 PHASE2; PHASE3
NCT03216278 COMPLETED
Healthy Subjects in Fasted and Fed State
AstraZeneca
 2017-09-26 PHASE1
NCT02740231 COMPLETED
Knee Osteoarthritis
Bone Therapeutics S.A
 2016-02 PHASE2; PHASE3
NCT01079013 UNKNOWN
Non Hodgkin Lymphoma; Hodgkin Lymphoma
Sheba Medical Center
 2010-03 PHASE2
NCT01665092 COMPLETED
Septic Shock
University of Mississippi Medical Center
 2013-01 PHASE2
NCT03101124 COMPLETED
Surgical Wound; Bleeding
St. Olavs Hospital
 2017-05-01 PHASE2
NCT02575534 WITHDRAWN
Arrhythmias
Evan Adelstein, MD
 2015-10
NCT03370497 COMPLETED
Obesity; Diabetes
University of Bath
 2017-10-01
NCT02132481 COMPLETED
Substance Use Disorder (SUD); Recovery
Chestnut Health Systems
 2015-06
NCT02424734 TERMINATED
Late-onset Sepsis
Pfizer
 2015-08-04 PHASE2
NCT01696669 COMPLETED
Ewing's Sarcoma
Grupo Espanol de Investigacion en Sarcomas
 2010-03-30 PHASE2
NCT00970866 COMPLETED
Anemia; Malnutrition; Stunting
University of California, Davis
 2009-11
NCT02203955 COMPLETED
Pouchitis
Mayo Clinic
 2014-08 PHASE1
NCT03846843 COMPLETED
Cirrhosis
Ocera Therapeutics, Inc.
 2016-08-15 PHASE1
NCT02350777 TERMINATED
Hematopoietic Stem Cell Transplant; Poor Marrow Graft Function
Memorial Sloan Kettering Cancer Center
 2015-01-21 PHASE2
NCT03113240 COMPLETED
Critical Illness; Enteral Nutrition; Intestinal Permeability
Shahid Beheshti University
 2017-04-01 PHASE3
NCT02728089 COMPLETED
Urinary Tract Infection (UTI); Complicated Urinary Tract Infection; Pyelonephritis; Uncomplicated Pyelonephritis
Merck Sharp & Dohme LLC
 2016-04-14 PHASE3
NCT00793676 COMPLETED
Asthma; COPD
University Hospital, Strasbourg, France
 2008-09
NCT01619020 COMPLETED
Healthy
Fred Hutchinson Cancer Center
 2012-10
NCT02449746 COMPLETED
Schizophrenia; Psychosis; Auto Immune Disorders
University of Cambridge
 2015-08
NCT03336853 COMPLETED
Blood Contamination of Root Canal During Endodontic Therapy
Dr Riccardo Pace
 2017-04-01
NCT01824940 COMPLETED
Growth; Stunting, Nutritional; Anemia
Johns Hopkins Bloomberg School of Public Health
 2012-11
NCT01033188 COMPLETED
Knee Outcome, Subjective
Oslo University Hospital
 2010-01
NCT02286219 COMPLETED
Solid Tumors That Overexpress HER2 (HER2 Positive)
Bristol-Myers Squibb
 2014-11-04 PHASE1
NCT01692197 COMPLETED
Leukemia
M.D. Anderson Cancer Center
 2013-02-01 PHASE2
NCT03105960 UNKNOWN
Gingival Bleeding
Cairo University
 2017-03-10
NCT02459535 COMPLETED
Pre-diabetes; Diabetes
German Institute of Human Nutrition
 2015-03
NCT02961972 COMPLETED
Endothelial Dysfunction; Hyperhomocysteinemia
National Institute of Cardiology, Laranjeiras, Brazil
 2015-01
NCT02682680 COMPLETED
Type 2 Diabetes Mellitus
LMC Diabetes & Endocrinology Ltd.
 2016-01-11 PHASE4
NCT02199041 TERMINATED
Hematological Malignancies
St. Jude Children's Research Hospital
 2014-07-11 PHASE2
NCT03586245 COMPLETED
Iron Absorption
Iowa State University
 2016-10-28
NCT03167918 COMPLETED
Type 2 Diabetes Mellitus; Pulmonary Function
Liaoning University of Traditional Chinese Medicine
 2014-07-21 PHASE2; PHASE3
NCT03294538 COMPLETED
Atrophic Vaginitis
Actavis Inc.
 2016-05-18 PHASE3
NCT02005419 COMPLETED
Stage IA Pancreatic Adenocarcinoma; Stage IB Pancreatic Adenocarcinoma; Stage IIA Pancreatic Adenocarcinoma; Stage IIB Pancreatic Adenocarcinoma
Xian-Jun Yu
 2013-12 PHASE2
NCT02337855 COMPLETED
Schistosomiasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2015-02-04 PHASE1
NCT02333058 COMPLETED
Acute Lymphoblastic Leukaemias (ALL); Acute Myeloid Leukaemias (AML); Myelodysplastic Syndromes (MDS); Juvenile Myelomonocytic Leukaemias (JMML)
medac GmbH
 2014-11-21 PHASE2
NCT02679222 COMPLETED
Healthy Adults
Université de Sherbrooke
 2015-06
NCT02847286 COMPLETED
HIV- Prevention
International Partnership for Microbicides, Inc.
 2015-09-01 PHASE1
NCT03416504 COMPLETED
Obsessive-Compulsive Disorder
University of North Carolina, Chapel Hill
 2015-09-22
NCT02734901 COMPLETED
Healthy
Heinrich-Heine University, Duesseldorf
 2016-03
NCT02279420 COMPLETED
Obesity
USGI Medical
 2015-01-05
NCT02459834 COMPLETED
Type 2 Diabetes
University of Toronto
 2015-11
NCT02666287 COMPLETED
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline
 2016-01-27 PHASE1
NCT02312492 COMPLETED
Dyslipidemia
Tufts University
 2013-01
NCT02116322 TERMINATED
Pancreatic Cancer
Johns Hopkins University
 2014-04
NCT03057535 COMPLETED
Pulmonary Ventilation
McGill University
 2015-05 EARLY_PHASE1
NCT03783845 COMPLETED
Chronic Periodontitis, Generalized
Taibah University
 2015-06-01 PHASE4
NCT02317549 TERMINATED
Septic Shock
Leading BioSciences, Inc
 2015-04 PHASE2
NCT01746303 COMPLETED
Age-related Memory Disorders; Mood Disorders
University of Cincinnati
 2010-01
NCT03528707 COMPLETED
Type2 Diabetes; NAFLD; Probiotic; Omega-3 Fatty Acids
Bogomolets National Medical University
 2015-04-14
NCT03655041 COMPLETED
Sports Nutritional Physiological Phenomena
University of Sao Paulo
 2013-02-01
NCT01537055 UNKNOWN
Eradication Rate for Helicobacter
National Taiwan University Hospital
 2012-02 PHASE4
NCT01208714 UNKNOWN
Renal Artery Stenosis
University Hospital Padova
 2010-12 PHASE4
NCT02533986 COMPLETED
Healthy
Lund University
 2015-08 PHASE1; PHASE2
NCT02130817 WITHDRAWN
End Stage Renal Disease; Antibody Mediated Rejection
University of Wisconsin, Madison
 2014-09-24 PHASE4
NCT02559141 COMPLETED
Perioperative/Postoperative Complications; C.Surgical Procedure; Digestive System
University Hospital Schleswig-Holstein
 2014-03
NCT02498782 UNKNOWN
Chagas Disease; Trypanosomiasis, South American; South American Trypanosomiasis; Disease, Chagas
Drugs for Neglected Diseases
 2014-07 PHASE2
NCT02098486 COMPLETED
Cholangitis
Kangbuk Samsung Hospital
 2014-03 PHASE2
NCT01661985 UNKNOWN
Urethritis; Cervicitis; Genital Mycoplasma Infection; Chlamydia Trachomatis
Ostergotland County Council, Sweden
 2010-02 PHASE4
NCT03956433 COMPLETED
Metabolic Syndrome
University of Leeds
 2014-09-01
NCT00450801 COMPLETED
Lymphoma
University of Miami
 2004-04 PHASE2
NCT03263104 COMPLETED
Healthy
University of Roehampton
 2015-01
NCT01186224 COMPLETED
Multiple Myeloma; Plasma Cell Dyscrasia; Lymphoma; Lymphoproliferative Disorders
University of Liverpool
 2010-05
NCT02416258 COMPLETED
Skin and Connective Tissue Diseases
LEO Pharma
 2015-04 PHASE2
NCT02423980 COMPLETED
Hypoglycemia
Xeris Pharmaceuticals
 2015-04 PHASE2
NCT02710513 COMPLETED
Healthy
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
 2014-12
NCT02899507 COMPLETED
Out-of-hospital Cardiac Arrest
University Medical Centre Ljubljana
 2013-09 PHASE4
NCT01143545 TERMINATED
Lung Cancer; Esophageal Cancer; Malignant Pleural Mesothelioma; Sarcoma; Thymic Carcinoma
National Cancer Institute (NCI)
 2010-12-07 PHASE1
NCT03108287 COMPLETED
Helicobacter Pylori Infection
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2013-04-01 PHASE4
NCT01343277 COMPLETED
Advanced Liposarcoma or Leiomyosarcoma
Janssen Research & Development, LLC
 2011-06 PHASE3
NCT01045460 COMPLETED
Multiple Myeloma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2010-01-15 PHASE2
NCT02224040 UNKNOWN
Typhoid Fever
Sheba Medical Center
 2013-08 PHASE4
NCT00253786 COMPLETED
Type 2 Diabetes Mellitus; Diabetic Nephropathy
Okayama University
 2005-11-11
NCT01594424 COMPLETED
End Stage Renal Disease (ESRD)
Cedars-Sinai Medical Center
 2012-06 PHASE1; PHASE2
NCT02414061 COMPLETED
Healthy
Northumbria University
 2014-04
NCT01502202 UNKNOWN
Non Small Cell Lung Cancer; Adenocarcinoma
National Cancer Center, Korea
 2012-03 PHASE2
NCT02108535 COMPLETED
Second-degree Burn
University of Sorocaba
 2013-11 PHASE4
NCT01548534 TERMINATED
Metastatic Breast Cancer; Progesterone Receptor Positive Tumor; Estrogen Receptor Positive Tumor; HER-2 Negative Tumor
University Hospital, Tours
 2012-02 PHASE3
NCT00914888 WITHDRAWN
Community Acquired Bacterial Pneumonia; Complicated Intra-Abdominal Infection
Wyeth is now a wholly owned subsidiary of Pfizer
 2011-01 PHASE3
NCT03589274 COMPLETED
Alcohol Use Disorder
Rutgers, The State University of New Jersey
 2010-06-01
NCT01026987 COMPLETED
Stem Cell Transplant Patients
Washington University School of Medicine
 2010-04-29 PHASE1
NCT01570582 UNKNOWN
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cancer
Korean Gynecologic Oncology Group
 2010-03 PHASE2
NCT02535897 COMPLETED
Muscle, Skeletal
University of Nottingham
 2013-07 PHASE1
NCT01976572 COMPLETED
Hyperphosphatemia; Chronic Kidney Disease
Tanabe Pharma Corporation
 2013-10 PHASE1
NCT01502982 COMPLETED
Diffuse Large B-Cell Lymphoma
Nordic Lymphoma Group
 2004-11 PHASE2
NCT01772875 WITHDRAWN
Catheter Related Infections
National Multiple Sclerosis Center
 2013-01
NCT02255812 COMPLETED
Exploratory Behavior
University Hospital, Basel, Switzerland
 2013-03
NCT01605929 WITHDRAWN
Anesthesia; Upper Extremity Injury
Brigham and Women's Hospital
 2012-07
NCT01874574 COMPLETED
Knee Osteoarthritis
Thammasat University
 2011-01 PHASE4
NCT01896492 COMPLETED
PCOS
Woman's Health University Hospital, Egypt
 2011-01 PHASE4
NCT02974348 COMPLETED
Drug Resistant Malaria Due to Plasmodium Falciparum
University of Bamenda
 2013-01 PHASE3
NCT01114516 COMPLETED
Cervical Insufficiency
Northwestern University
 2010-03
NCT01219764 COMPLETED
Helicobacter Infections
American University of Beirut Medical Center
 2010-10 PHASE4
NCT00313716 COMPLETED
Anemia; Traumatic Brain Injury
Claudia Sue Robertson
 2006-04 PHASE2; PHASE3
NCT03212040 COMPLETED
Breast Biopsy
University Hospital Tuebingen
 2011-12-05
NCT01637493 UNKNOWN
Neutropenia
Hangzhou Jiuyuan Gene Engineering Co. Ltd.,
 2012-02 PHASE1
NCT01723059 UNKNOWN
Helicobacter Infection
Dallas VA Medical Center
 2012-02
NCT01837199 COMPLETED
Chronic Periodontitis; Smoking
University of Guarulhos
 2011-07 PHASE4
NCT01843296 COMPLETED
Lumbar Spine Disc Herniation
Isfahan University of Medical Sciences
 2012-11 PHASE4
NCT01579786 UNKNOWN
Post Operative Pain
University of Padova
 2011-05
NCT00286182 COMPLETED
Anemia
Mathew S. Maurer
 2007-07 PHASE2
NCT01645124 TERMINATED
Polycythemia Vera
Consorzio Mario Negri Sud
 2008-05 PHASE3
NCT00287586 COMPLETED
Hypogonadism; Atherosclerosis
Brigham and Women's Hospital
 2004-09 PHASE4
NCT01043536 COMPLETED
Glioblastoma
Centre Georges Francois Leclerc
 2009-09 PHASE1
NCT01644539 COMPLETED
Appetite Regulation
UMC Utrecht
 2011-07
NCT00544778 TERMINATED
Sarcoma
City of Hope Medical Center
 2001-08 PHASE2
NCT01039103 TERMINATED
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis; Clinically Isolated Syndrome
Lakefront Biotherapeutics NV
 2009-12 PHASE2
NCT02389452 COMPLETED
Osteoarthritis
Genzyme, a Sanofi Company
 2010-02 PHASE4
NCT01016262 TERMINATED
Proctitis, Ulcerative
Forest Laboratories
 2009-11-30 PHASE3
NCT00644150 COMPLETED
HIV Infections; Gonorrhea; Chlamydia
University of California, Los Angeles
 2007-04
NCT01402648 COMPLETED
Adenocarcinoma of Colon Recurrent
CM&D Pharma Limited
 2009-10 PHASE1; PHASE2
NCT00054236 COMPLETED
Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases
Case Comprehensive Cancer Center
 2002-05 PHASE1
NCT00511810 COMPLETED
Major Depressive Disorder
University of Cincinnati
 2007-08 PHASE2; PHASE3
NCT01456572 COMPLETED
Endocrine System Diseases
University Hospital, Basel, Switzerland
 2007-01 PHASE1
NCT00283400 TERMINATED
Subarachnoid Hemorrhage
Baylor College of Medicine
 2006-01
NCT01181700 COMPLETED
Pharmacokinetics
Pfizer
 2010-10 PHASE1
NCT01428401 COMPLETED
Stroke; Hemorrhagic Transformation Due to Acute Stroke
China Medical University Hospital
 2008-01 PHASE2
NCT00315133 COMPLETED
Type 1 Diabetes Mellitus
University of Sao Paulo
 2003-12 PHASE1; PHASE2
NCT00430677 TERMINATED
Systemic Lupus Erythematosus
Bristol-Myers Squibb
 2007-06 PHASE2; PHASE3
NCT01677611 COMPLETED
Type 2 Diabetes
Khoo Teck Puat Hospital
 2008-12 PHASE1
NCT00437684 UNKNOWN
HIV Infections; Hepatitis C
IRCCS San Raffaele
 2007-02 PHASE3
NCT00746811 COMPLETED
Primary Hypercholesterolemia
Provident Clinical Research
 2010-01 PHASE4
NCT00570960 TERMINATED
Spontaneous Bacterial Peritonitis
University of Virginia
 2007-06 PHASE4
NCT00438321 TERMINATED
Metabolic Syndrome
Massachusetts General Hospital
 2006-09 PHASE1
NCT01316016 COMPLETED
Obesity
Lund University
 2009-04
NCT00433381 COMPLETED
Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Neoplasm
National Cancer Institute (NCI)
 2007-03-01 PHASE2
NCT00718354 COMPLETED
Gastric Cancer; Gastroesophageal Cancer
Thrombosis Research Institute
 2008-07 PHASE3
NCT00862134 TERMINATED
Non-Small Cell Lung Cancer
Proacta, Incorporated
 2009-03 PHASE2
NCT01484457 COMPLETED
Diabetes Mellitus, Type 1
Sansum Diabetes Research Institute
 2008-07 EARLY_PHASE1
NCT00442910 COMPLETED
Healthy
Starpharma Pty Ltd
 2007-07 PHASE1
NCT02624141 TERMINATED
Anemia
Hoffmann-La Roche
 2006-04 PHASE4
NCT01858090 COMPLETED
Elective Caesarean Section Surgeries
Baskent University
 2009-01 PHASE3
NCT01856205 COMPLETED
Japanese Encephalitis
University of Liverpool
 2009-05 PHASE2
NCT01005927 COMPLETED
Osteoporosis
Purdue University
 2009-01 PHASE1; PHASE2
NCT00825994 COMPLETED
Depression
Massachusetts General Hospital
 2008-11
NCT00694642 COMPLETED
Coronary Artery Disease; Refractory Angina
Pilar Jimenez Quevedo
 2008-05 PHASE1; PHASE2
NCT00377260 COMPLETED
Acute Otitis Media
University of Pittsburgh
 2006-11 PHASE4
NCT00661063 UNKNOWN
Diabetic Neuropathy; Pain
Irmandade da Santa Casa de Misericordia de Sao Paulo
 2008-04 PHASE3
NCT00850590 COMPLETED
Incontinence
Norgine
 2009-02 PHASE1
NCT00723502 COMPLETED
Gram-Negative Bacterial Infections; Helicobacter Infections; Dyspepsia
MerLion Pharmaceuticals GmbH
 2008-09 PHASE2
NCT00785330 COMPLETED
Non-Hodgkin's Lymphoma
Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
 2004-04 PHASE2
NCT00875797 TERMINATED
Critically Ill
University Medical Centre Ljubljana
 2004-10 PHASE4
NCT01333787 COMPLETED
Constipation
Federal University of São Paulo
 2008-02 PHASE4
NCT01617811 COMPLETED
Hepatectomy
Sir Run Run Shaw Hospital
 2007-08
NCT00364845 TERMINATED
Anemia; Chronic Kidney Disease
Amgen
 2006-09 PHASE3
NCT00705900 COMPLETED
Chronic Plaque Psoriasis
NeoStrata Company, Inc.
 2007-01
NCT00280683 COMPLETED
Asthma
University of California, Davis
 2004-12 PHASE2
NCT00451646 COMPLETED
Parenteral Nutrition
Fresenius Kabi
 2007-10 PHASE3
NCT00461955 COMPLETED
Multiple Myeloma
University Hospital, Bordeaux
 2007-08 PHASE2
NCT01250080 COMPLETED
Moderate to Severe Trauma, as Defined by an; Injury Severity Score (ISS) > 12 Points Were Included in the Study.
Hospital Universitari Son Dureta
 2007-01
NCT00724750 COMPLETED
Acute Wounds From Trauma; Dehiscence or Surgical Complications
University of Chicago
 2006-07
NCT00990847 COMPLETED
Moderate Acute Asthma
PT Otsuka Indonesia
 2007-06 PHASE3
NCT00268788 COMPLETED
Multifocal Motor Neuropathy
University of Aarhus
 2005-08 PHASE2
NCT00529282 TERMINATED
Fever; Neutropenia; Gram-positive Bacterial Infections; Pseudomonas Infection
Basilea Pharmaceutica
 2007-10 PHASE3
NCT01012843 COMPLETED
Anal Fistula
Ankara University
 2005-09
NCT04555460 COMPLETED
Cerebral Herniation
Ege University
 2003-01-23
NCT00657124 COMPLETED
Liver Disease
Kochi University
 2007-04 PHASE4
NCT00337987 COMPLETED
Peripheral T-Cell Lymphoma
Yale University
 2005-11 PHASE2
NCT00769132 COMPLETED
Hypercholesterolemia
Merck Sharp & Dohme LLC
 2007-08-03 PHASE1
NCT02608060 TERMINATED
Anemia
Hoffmann-La Roche
 2006-09 PHASE4
NCT00456339 TERMINATED
Obstructive Sleep Apnea Syndrome
University of Chicago
 2006-07 PHASE4
NCT01005342 COMPLETED
Hypoglycemia; Hyperglycemia
Lund University
 2007-05
NCT00253955 COMPLETED
Pneumonia
Sanofi
 2003-06 PHASE3
NCT00146562 COMPLETED
Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer
Harold J. Burstein, MD, PhD
 2003-07 PHASE2
NCT00432484 COMPLETED
Rheumatoid Arthritis
Chinese University of Hong Kong
 2005-05 PHASE2
NCT01121471 COMPLETED
Diabetes Mellitus
Ohio State University
 2004-12
NCT00494949 COMPLETED
Hypotension; Hypoxia
Sangart
 2003-04 PHASE1; PHASE2
NCT00103610 COMPLETED
Lymphoma, Non-Hodgkin
Genzyme, a Sanofi Company
 2005-01 PHASE3
NCT00586014 COMPLETED
Multiple Myeloma
Duke University
 1997-05 PHASE2
NCT00005800 COMPLETED
Breast Cancer
H. Lee Moffitt Cancer Center and Research Institute
 1999-04 PHASE2
NCT00039481 COMPLETED
Cardiac Toxicity; Unspecified Childhood Solid Tumor, Protocol Specific
National Cancer Institute (NCI)
 2002-11 PHASE1
NCT00395967 TERMINATED
Multiple Myeloma; Lymphoma, Non-Hodgkin's
Genzyme, a Sanofi Company
 2005-04 PHASE2
NCT01371175 COMPLETED
HIV Infections
International AIDS Vaccine Initiative
 2003-04 PHASE2
NCT00769418 COMPLETED
Osteoporosis
Merck Sharp & Dohme LLC
 2004-09 PHASE1
NCT00763997 COMPLETED
Platelet Aggregation
Ruhr University of Bochum
 2004-02
NCT00407342 COMPLETED
Psoriasis
Medical University of Graz
 2004-02
NCT00003691 COMPLETED
Endometrial Cancer
Gynecologic Oncology Group
 1998-12 PHASE3
NCT00005810 COMPLETED
Prostate Cancer
Alliance for Clinical Trials in Oncology
 2000-03 PHASE2
NCT00836901 COMPLETED
Healthy
Teva Pharmaceuticals USA
 2003-09 PHASE1
NCT00160264 COMPLETED
Osteopenia
Solvay Pharmaceuticals
 2003-01 PHASE4
NCT00422617 COMPLETED
Chronic Plaque Psoriasis
Uni-Pharma
 2005-01
NCT00006578 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01020279 COMPLETED
Musculoskeletal Pain
X-pert Med GmbH
 2009-10 PHASE1
NCT01310361 COMPLETED
Streptococcal Sore Throat
Azad University of Medical Sciences
 2004-01 PHASE1
NCT00307879 TERMINATED
Myocardial Infarction
Seoul National University Hospital
 2004-03 PHASE2
NCT00643227 COMPLETED
Pneumonia
Pfizer
 2003-01 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-08-31)

Check the Pronase E (Activity ≥ 7000 U/g) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Pronase E, a non-specific protease mixture derived from Streptomyces griseus, hydrolyzes peptide bonds across extracellular matrix proteins and cell-surface receptors to disrupt critical peptide signaling networks and cell adhesion cascades. This broad proteolytic degradation impairs key cellular survival pathways and destabilizes membrane integrity, providing therapeutic potential in conditions ranging from sepsis and inflammatory disorders to advanced malignancies like small cell lung carcinoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.