CAS No. 500-92-5

Batch: Purity:99.93
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Proguanil Chemical Structure
Chemical Structure
Check the Proguanil product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
CAS Number 500-92-5
Molecular Formula

C11H16ClN5
Molecular Weight (MW) 253.73
SMILES CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
InChIKey SSOLNOMRVKKSON-UHFFFAOYSA-N

Ordering Information

Biological Activity

Proguanil is an antimalarial agent that targets plasmodial dihydrofolate reductase to disrupt the folate biosynthesis pathway. By blocking the synthesis of purines and pyrimidines, proguanil inhibits essential nucleic acid production, impairing DNA synthesis and parasite cell multiplication. Additionally, proguanil acts synergistically with other antimalarial compounds to collapse mitochondrial membrane potential, ultimately leading to the inhibition of plasmodial proliferation and survival. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 51 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.