CAS No. 92-62-6
Batch:
Purity:98.04
Chemical Structure
Check the
Proflavine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | acridine-3,6-diamine | |
|---|---|---|
| CAS Number | 92-62-6 | |
| Molecular Formula |
C13H11N3 |
|
| Molecular Weight (MW) | 209.25 | |
| SMILES | C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N | |
| InChIKey | WDVSHHCDHLJJJR-UHFFFAOYSA-N |
Biological Activity
Proflavine (3,6-Diaminoacridine) is an acridine dye and topical antiseptic agent with bacteriostatic activity against many Gram-positive bacteria. It acts primarily by intercalating between nucleic acid base pairs, directly disrupting DNA structure and inhibiting nucleic acid synthesis. This intercalation blocks DNA replication and transcription pathways, resulting in the suppression of bacterial cell proliferation and viability.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
23 mg/mL
(109.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
Note: Technical data last updated: Sep 1, 2026.