CAS No. 29106-49-8

Batch: Purity:99.94
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Procyanidin B2 (PCB2) Chemical Structure
Chemical Structure
Check the Procyanidin B2 (PCB2) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
CAS Number 29106-49-8
Molecular Formula

C30H26O12
Molecular Weight (MW) 578.52
InChIKey XFZJEEAOWLFHDH-NFJBMHMQSA-N

Biological Activity

Procyanidin B2 (PCB2) is a natural flavonoid with potent anti-inflammatory, antioxidant, and antitumor activities. It functions as a peroxisome proliferator-activated receptor gamma (PPARγ) activator, inducing M2 macrophage polarization. Additionally, PCB2 suppresses NLRP3 inflammasome activation and inhibits downstream pro-inflammatory cytokine release in lung tissue models. Through these signaling modulations, PCB2 attenuates oxidative stress, reduces inflammatory tissue damage, and inhibits cancer cell proliferation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (172.85 mM) ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.