CAS No. 1575596-29-0,1575591-66-0
Batch:
Purity:99.05
Chemical Structure
Check the
PRN1008
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | |
|---|---|---|
| CAS Number | 1575596-29-0,1575591-66-0 | |
| Molecular Formula |
C36H40FN9O3 |
|
| Molecular Weight (MW) | 665.76 | |
| SMILES | CC(C)(/C=C(C#N)/C(=O)N1CCC(CC1)[N]2N=C(C3=C(F)C=C(OC4=CC=CC=C4)C=C3)C5=C2N=CN=C5N)N6CCN(CC6)C7COC7 | |
| InChIKey | LCFFREMLXLZNHE-GBOLQPHISA-N |
PRN1008 (Rilzabrutinib) is an orally active, selective, and reversible covalent inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of. By targeted inhibition of BTK, it blocks downstream B-cell receptor (BCR) signaling pathways, thereby suppressing B-cell activation, proliferation, and pro-inflammatory cytokine production. This pathway inhibition effectively dampens autoantibody-mediated immune activation and inflammatory responses in cellular and preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(150.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.