CAS No. 346688-38-8
Batch:
Purity:98.59
Chemical Structure
Check the
Pridopidine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 346688-38-8 | |
|---|---|---|
| Molecular Formula |
C15H23NO2S |
|
| Molecular Weight (MW) | 281.42 | |
| SMILES | CCCN1CCC(CC1)C2=CC(=CC=C2)[S;v6](C)(=O)=O |
Pridopidine is a dopamine stabilizer that acts as an antagonist against the sigma-1 receptor (S1R) and dopamine D2 receptor (D2R). Activation of S1R signaling by pridopidine restores endoplasmic reticulum calcium homeostasis, reduces store-operated calcium entry, and prevents dendritic spine loss in neuronal models. Downstream, pridopidine upregulates pro-survival molecules such as BDNF and DARPP32, attenuating mutant huntingtin toxicity and promoting neuronal cell survival. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(202.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.