CAS No. 2479378-45-3
Batch:
Purity:99.05
Chemical Structure
Check the
PRGL493
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[4-[3-(5-methylfuran-2-yl)-1-phenylpyrazol-4-yl]-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-yl]acetamide | |
|---|---|---|
| CAS Number | 2479378-45-3 | |
| Molecular Formula |
C25H21N7O2 |
|
| Molecular Weight (MW) | 451.48 | |
| InChIKey | QNWGOBIYAPLFMK-UHFFFAOYSA-N |
Biological Activity
PRGL493 is a selective inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4). By impeding ACSL4-mediated conversion of arachidonic acid into arachidonoyl-CoA, it modulates intracellular lipid metabolism and suppresses de novo steroidogenesis. Downstream, PRGL493 blocks cell proliferation and attenuates tumor growth in both breast and prostate cancer models while sensitizing tumor cells to chemotherapeutic and hormonal therapies. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
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|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(17.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.