CAS No. 1852-38-6

Batch: Purity:98.79
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Pregnenolone monosulfate sodium Chemical Structure
Chemical Structure
Check the Pregnenolone monosulfate sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium (17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) sulfate
CAS Number 1852-38-6
Molecular Formula

C21H32O5S.Na
Molecular Weight (MW) 419.53
InChIKey QQVJEIZJHDPTSH-UHFFFAOYSA-M

Ordering Information

Biological Activity

Pregnenolone monosulfate sodium is an active endogenous neurosteroid and precursor to steroid hormones that acts as a potent, signal-specific negative allosteric inhibitor of cannabinoid CB1 receptors. By modulating CB1 receptor signaling, it inhibits the activation of downstream intracellular pathways induced by Δ9-tetrahydrocannabinol. This neuroprotective mechanism effectively mitigates CB1-mediated signaling hyperactivation and reduces psychoactive phenotypes associated with tetrahydrocannabinol exposure.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 2 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.