CAS No. 125-02-0

Batch: Purity:99.66
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Prednisolone disodium phosphate Chemical Structure
Chemical Structure
Check the Prednisolone disodium phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 125-02-0
Molecular Formula

C21H27Na2O8P
Molecular Weight (MW) 484.39
SMILES [Na+].[Na+].CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO[P]([O-])([O-])=O

Ordering Information

Biological Activity

Prednisolone disodium phosphate is a synthetic glucocorticoid receptor agonist with potent anti-inflammatory and immunomodulating activities. Upon binding to the glucocorticoid receptor, it modulates gene transcription, inhibiting pro-inflammatory cytokine signaling while promoting immunosuppressive pathways. Additionally, this compound exerts biphasic and late mitogenic effects on glucocorticoid-resistant acute lymphoblastic leukemia cells, modulating cell proliferation and apoptotic responses in hematopoietic malignancies.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 97 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.