CAS No. 150821-03-7
Batch:
Purity:99.68
Chemical Structure
Check the
Pranlukast hemihydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 150821-03-7 | |
|---|---|---|
| Molecular Formula |
C27H23N5O4.1/2H2O |
|
| Molecular Weight (MW) | 490.51 |
Pranlukast hemihydrate is a selective antagonist of cysteinyl leukotriene receptor-1 (CysLT1). By blocking the binding of leukotrienes, including LTC4, LTD4, and LTE4, it attenuates bronchoconstriction and airway inflammation. Additionally, Pranlukast inhibits NF-κB pathway activation, thereby downregulating the release of proinflammatory cytokines such as IL-1, IL-6, and TNF-α from monocytes and macrophages to exert broad immunomodulatory effects. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(203.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.