CAS No. 78478-28-1

Batch: Purity:99.88
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Praeruptorin E Chemical Structure
Chemical Structure
Check the Praeruptorin E product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(9S,10S)-8,8-dimethyl-10-(3-methylbutanoyloxy)-2-oxo-9,10-dihydropyrano[2,3-f]chromen-9-yl] (Z)-2-methylbut-2-enoate
CAS Number 78478-28-1
Molecular Formula

C24H28O7
Molecular Weight (MW) 428.47
SMILES CC=C(C)C(=O)OC1C(C2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C)OC(=O)CC(C)C
InChIKey UFUVJROSOIXJGR-WLISBCLRSA-N

Ordering Information

Biological Activity

Praeruptorin E, a natural coumarin isolated from Peucedanum praeruptorum Dunn., functions as a cardiotonic agent with selective cardiac calcium channel agonistic activity. By activating cardiac calcium channels, Praeruptorin E modulates transmembrane calcium influx in cardiomyocytes. This enhancement of intracellular calcium signaling promotes positive inotropic responses and regulates cardiac contractile function, highlighting its potential role in modulating cardiovascular physiology. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 43 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.