CAS No. 72463-77-5
Batch:
Purity:99.99
Chemical Structure
Check the
Praeruptorin C
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 72463-77-5 | |
|---|---|---|
| Molecular Formula |
C24H28O7 |
|
| Molecular Weight (MW) | 428.47 | |
| SMILES | CC=C(C)C(=O)OC1C(C2=C(C=CC3=C2OC(=O)C=C3)OC1(C)C)OC(=O)CC(C)C |
Praeruptorin C is a natural pyranocoumarin that acts as an inhibitor of osteoclastogenesis and bone resorption. It suppresses RANKL-induced signaling by downregulating the NF-κB and MAPK signaling pathways, leading to the inhibition of key transcription factors such as NFATc1. This pathway inhibition reduces osteoclast differentiation and protects against inflammatory bone loss in preclinical models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(46.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
86 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.